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Different stressors and role of acupuncture intervention on psychological and NEI network changes

Author: ZhengYu
Tutor: ZhangLuFen
School: Beijing University of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: Acupuncture and moxibustion Neuro-endocrine-immune network (NEI) Adjuvant arthritis (AA) Bandage stress mental and psychology
CLC: R245
Type: Master's thesis
Year: 2007
Downloads: 143
Quote: 1
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Abstract


The distinctive quality of acupuncture and moxibustion treatment, had decided the ambiguity effect both the biology effect and the psychology effect.The present situation of the acupuncture and moxibustion research lays undue stress on its biology effect, but neglects the psychological factor the function, to understanding the acupuncture and moxibustion treatment function is not comprehensive.As traditional the method of treatment as the acupuncture and moxibustion is effective, its whole adjustment superiority has, in the development and the course of treatment psychology effect multiple control mechanism to the disease must conduct further the thorough research.This experiment according the earlier period experiment foundation, attempts continue to observe the acupuncture and moxibustion to bondage stress model, adjuvant arthritis (AA)model rat’s influence, pointing at experiment environment change as well as treatment timechoice,and according neuro-endocrine-immune network theory, which Promulgates partial mechanisms that whole regulation of the acupuncture and moxibustion to controlling the influnce of neuro-endocrine-immune network by the different stress to changing the mental condition.The experiment bondage stress model, adjuvant arthritis model took the research object, Useing technical method to exam brain and the blood and so on by the immunology, immunity histochemistry, emission immunity the nerve handsover the nature, the peptide class matter and the cell factor and soon,observes acupuncture’s influence to the model which immunity is out of balance led by different stressor. The experiment uses male Wistar rat 120, randomly divided into 3 groups: The control group, the model group( bondage stress model group, the AA model group),The therapy group( the AA acupuncture and moxibustion Guanyuan,Mingmen and Zusanli group, the bondage stress model acupuncture and moxibustion Guanyuan,Mingmen and Zusanli group), each group of 8.The experimental conclusion is, the acupuncture regulating action is various, the multi- links, the multi- ways, the multi- levels, the acupuncture to the nerve, the endocrine, the immunity three systems has the control action, main result as follows:1. The acupuncture and moxibustion took one kind external stimulates with inflammation by AA model and bandage stress, which stir up the presentiment organism together, As the benefit stressor regulate the balance of body, acupuncture and moxibustion is different the The vicious stimulates by AA model and bandage stressing.2. The acupuncture and moxibustion should regulate multiple effect factors such as IL-1,TNF-α,which participating in unbalance of internal environment. Giving prominence to the characters of multiple effect factors not only in inflammation responded but also in mental and psychology.3. The acupuncture and moxibustion should regulate IL-2 with the different functional condition of neuro-endocrine-immune network.4. The acupuncture and moxibustion should regulate Lymphocyte increment rate change by stressing though inflammation, bandage stress, and horror-struck stress.5. The acupuncture and moxibustion should enhance the inducing function between IL-2 and IL-1,TNF-α,which improving cooperation or antagonism function, as same as inducing and maintaining the balance regulation of those cell factors.6. componding Biology activeness ofμreceptor and IL-2, unifies IL-2 in spiritual, psychological, the behavior aspect function, we extrapolatedμreceptor has played the vital role in the acupuncture bidirectional adjustment process.7. Through adjustment plant nerve in sympathetic nervous system, we extrapolated theβ-EP andμreceptor’function of participating psychological stress.The acupuncture and moxibustion took one benefit stressor should stir up the presentiment organism , adjusting disorder function, finally having been achieved sharpened the organism intrinsic strain capacity.8. The acupuncture and moxibustion should regulate relationship of COR,CRH,ACTH and AVP on the HPA axis.

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