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The acupuncture model rat immune dysfunction relevant factors and neurotransmitter

Author: ZhangFan
Tutor: ZhangLuFen
School: Beijing University of Traditional Chinese Medicine
Course: Acupuncture and Massage
Keywords: Acupuncture and moxibustion Neuro-endocrine-immune network Adjuvant arthritis (AA) Bandage stress
CLC: R245
Type: Master's thesis
Year: 2008
Downloads: 123
Quote: 0
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Abstract


The acupuncture and moxibustion took traditional the method of treatment is effective, its wholly adjustment superiority is gradually approved, but the acupuncture and moxibustion mechanism explanation still paused in the traditional theory foundation. Although already carried on the massive research work but still not to be able to be satisfying. To acupuncture and moxibustion preventing and controlling, the prevention disease function mechanism conducts further the thorough research, was still necessary. Perhaps the micro examination, the macro synthesis is a mentality.This experiment at in the earlier period experiment foundation, Guanyuan, Baihui, Zusanli acupoints were adopted as research object, under each’s commonness and speciality in traditional Chinese mecidine, attempts to continue to observe the electro-acupuncture to bondage stress model, adjuvant arthritis (AA)model rat’s influence through changes of cell factors in molecular biology level, according neuro-endocrine-immune network theory, promulgates the acupuncture and moxibustion wholly regulation the partial mechanisms.The experiment takes the bondage stress model, adjuvant arthritis model as the research object, in which such skills as RIA, the pain threshold of detection techniques are used to examine the level of cell factors and nervous peptide class, and observed the influence of acupuncture and moxibustion to the models which immunity is out of balance led by different stressor. The experiment uses male Wistar rat 72, randomly divided into 9 groups: The normal group, the AA model group, the bondage stress model group, the AA needle Guanyuan group, the AA needle Baihui group, the AA needle Zusanli group, the bondage stress model needle Guanyuan group, the bondage stress model needle Baihui group, the bondage stress model needle Zusanli group, each group of 8.The experimental conclusion is, the acupuncture regulating action is various, the multi- links, the multi- ways, the multi- levels, the acupuncture to the nerve, the endocrine, the immunity three systems has the control action, main result as follows:1. The acupuncture can relieve the Inflammatory reaction degree of the organism to the Inflammatory through the dual control action to the rat blood serum IL-4、IL-6、IL-10 level.2. The acupuncture has the dual control action to the rat blood serum IL-6level: For significantly reduced to the state to the AA model rat performance, to bondage stress model of rats showed significant increases, which Guanyuan point performance most prominent.3. Acupuncture can regulate the production of serum and the release of PGE2, which mediated inflammatory response play the role of anti-inflammatory analgesic, to reduce adverse stimulation on the body caused by injury, enhance the body’s anti-injury ability.4. Acupuncture in the brain can adjust the overall OFQ and plasma nociceptin the secretion and release, and then in two different models of the immune status of the overall play of acupuncture, a two-way regulatory function through a multi-target, multi-link The adjustment to achieve the different sources of stress caused by immune dysfunction and pain of regulation.5. Guanyuan points on the body’s inflammatory response regulation is better than Zusanli and Baihui point, and the role of the worst Baihui points at the same time, Guanyuan point, Baihui points and Zusanli immune dysfunction in the prevention and treatment of disease With their respective laws and characteristics of the different models and the regulating role of different, reflects the acupoints specific characteristics.6. Acupuncture available through the central, peripheral, such as different levels of the role of neurotransmitters in the body regulate immune factors and related the synthesis and release, and then act on the nerve - endocrine - Immune Network, and through this network multi-level, multi-level, multi The common target, a wide range of functions, thereby enhancing the body of adverse external stress resistance, outside of the body and reduce the harm to the minimum. Acupuncture that role, as the impact of various internal factors, reflects the diversity and complexity of the side, but also proved that acupuncture in the neural control - endocrine - immune network in various neurotransmitters, the inherent complexity of cytokines mechanism.

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