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Study on Apolipoprotein E Gene Polymorphisms and Neuroelectrophysiology in Alzheimer’s Disease

Author: DuHongJian
Tutor: ChengZuo
School: Tianjin Medical University
Course: Neurology
Keywords: Alzheimer's disease ApoE gene ApoE promoter P300 visual evoked potential auditory evoke potential electroencephalography chaos.
CLC: R749.16
Type: PhD thesis
Year: 2002
Downloads: 170
Quote: 1
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Abstract


Objective: Alzheimer's disease (Alzheimer's disease, AD) is one of the main cause of senile dementia, currently the exact cause is not clear, but certainly related to genetic and find relevant genes AD research hotspot. This this topic apolipoprotein E gene and its promoter region-491A / T,-427T / C polymorphism was analyzed to explore with people the pathogenesis of AD relationship. Difficult for the early diagnosis of AD, the lack of specificity of clinical biological indicators for the comprehensive analysis of this topic and explore the patients with mild to moderate AD auditory event-related potentials (the auditory eventrelated potential A-ERP) (also known as P300), visual evoked potentials (visual evoke potential VEP), brainstem auditory evoked potentials (auditory brain-stem response, ABR), the performance of the electroencephalogram (eiectroencephalography, EEG) and the possible mechanism. And in the country for the first time in reference to the principle of nonlinear chaotic dimension to AD EEG quantitative analysis to help provide for the early diagnosis of AD. The first part of the Alzheimer's disease apolipoprotein E gene and its promoter region gene polymorphism in a clinical diagnosis of AD: disorder diagnostic and statistical manual of the American Psychiatric Fourth Edition Revision (DSM-IV-R) dementia diagnostic criteria and the U.S. National Institutes of language barriers Stroke Institute and AD diagnostic criteria for Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) by the Simple Intelligence Scale (mini-mental state examination, MMSE), and old age cognitive functional rating scale (the scale of elder cognitive function, SECF) screened 35 patients with clinical diagnosis of AD, and to assess the degree of dementia according to the Clinical Dementia Rating Scale (CDR). 38 age, gender, education level matched healthy elderly controls. Tianjin Medical University doctoral thesis, using the polymerase chain reaction - restriction fragment length polymorphism (NLP) method for detection of apolipoprotein E gene (Apolipoprotein E ApOE) polymorphism, the results show the AD group 4-bit gene (4) frequency was significantly higher than that in the control group (P <0 knife 5), in which 3/4 gene mainly help APoE. 4 is a risk factor for AD. AD group was divided into carry. 4 (4 +) and non-carriers (4 -), and the observed age of onset, results. 4 + ratio. - Age of onset; further gender comparison results. Four pairs of male age of onset is not obvious ...> O. 05X females. 4 + age of onset was significantly low dry. 4 <0 knife 5 people speculate E 4 not only increases the risk of AD, but also can reduce the AD, especially female age at onset of AD, indicating women. 4 + AD predisposing factors. Third, using the polymerase chain reaction - restriction fragment length polymorphism (PCR-IWLP) detected ApOE gene promoter region bucket 91A / T and-427T the sinks gene polymorphism of the results between the two groups, regardless of * 91 The * T gene, or 427DC gene polymorphism had no significant differences towel> 5 0 knife further its relationship with ApOE found. TC genotype 2 and * 27TC closely related at all. 2 carriers, 60% TC type, rather than. The 2 carriers only 5.3% TC, between both the possible concomitant of people were highly significant differences towel Diao knife, which have not been reported in the past. These results suggest that the muscle of the ApoE gene promoter region-49I,-427T / C polymorphism is not a risk factor for this group of AD onset. The second part of the fan disease Alzheimer neurophysiological study, 23 patients with mild to moderate AD as research subjects and the the ZI age, gender, educational level matched healthy elderly control check as follows: First, the hearing event-related potentials (P300) and The evoked auditory puzzle non-target identification assay P300. The observed NI, PZ, NZ, P3 incubation period and amplitude of P3. Results: with the control group than the AD group only P3 latency was significantly longer in power knife 1L rest were not different; further AD mild to moderate two groups compared to the control group, three groups P3 two Tianjin Medical University Doctoral Dissertation incubation period and volatility by analysis of variance significant differences towel power knife pairwise comparisons p the Diao knife 5 light in two subgroups n incubation period was significantly prolonged in 0 knife and one network volatility only moderate group decreased significantly ... 0.05 \\ by relevant The analysis shows that the N the latency MM Tian, ??fat C score was negatively correlated with towel-edged knife); AD group P3 incubation period total abnormal rate sl. 8%, the mild group was 728%, 100% of the moderate group. These results suggest that P3 latency is one of the manifestations of AD patients early electrophysiological, and more sensitive to early diagnosis of dementia, the degree of cognitive impairment P3 incubation period can also be used as a means assessment. Visual evoked potential (VEP) black-and-white checkerboard flip mode induced VEP observed N75, P 100, N135, P200 incubation period and volatility. Result: with the control group than the AD group N75, P100, N135 was no significant difference only n00 latency was significantly prolonged ... Diao knife); nOO latency MM * E, the sub * F score was negatively correlated ... power further light, the two groups and the control group, N135, P200 incubation period of three groups by analysis of variance differences. The pairwise comparisons P200 incubation period of light in the two groups also significantly extend the towel <0. of income while the N135 incubation period in the group only extended T <0.05 person description of early AD patients had VEP abnormalities and the abnormal change with the

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CLC: > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder > Elderly as early as possible the old disorder
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