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Bronchial asthma molecular genetics research

Author: GaoJinMing
Tutor: LinYaoGuang;QiuChangChun
School: Peking Union Medical College , China
Course: Respiration within the science
Keywords: polymorphism asthma gene HLA-DQ TNFα/LTα polymerase chain reaction β-adrenergic receptor-β2-agonist pedigree genetics
CLC: R562.25
Type: PhD thesis
Year: 2001
Downloads: 283
Quote: 0
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Executive Summary


Background and Objective: Bronchial asthma is complex genetic disease, the development of which is determined by host susceptibility and environmental exposure. Asthma is characterized by chronic airway inflammation. HLA class II genes have been identified one of candidate locus for asthma and asthma-related phenotype. HLA class II genes are highly polymorphic, and include DR, DP, and DQ. It has already shown that different HLA products or genes seems to represent risk for or protective factors against in the development of asthma. TNFα is pleiotrophic cytokines which orchestrates immune inflammatory response in the pathogensis of asthma, TNFa gene polymorphism has been shown to be associated with an enhanced transcription of TNFa. LTa gene of being disease marker have been applied for disease-associated study. The β2-adrenergic receptor gene (β2-AR) is on chromosome 5q31-33 within the region that had been linked to asthma. Three of β2-AR gene SNPs affect the function of β2-AR and the response to β2-agonist.The purpose of this study was to investigate the associations between the aboved genes polymorphism and asthma, asthma-related phenotypes by using molecular biological methods.Methods:In 125 Han origin asthmatics and 96 normal healthy controls with same ethnic nearby Beijing region, we analyzed the following items:(1) Asthma questionnaire: symptom, nocturnal wheezing, asthmatic sign score and asthma-specific life quality, allergy, family history, smoking history, et al.(2) The measurement of the TIgE, slgE (specific to d1, d2, mx2) and screening allergen by the method of RAST.(3) Evaluation of pulmonary ventilatory function (FEV1, FEV1%, FEV1/FVC), bronchial responsiveness challenged by Mch (FEV1%>70%), brocho-reversibility

Full-text Catalog


Research line     4-5
Introduction     5-6
Chinese Abstract     6-10
English summary     10-15 < br /> the first part : HLA -DQA , - DQB gene polymorphism and bronchial asthma and atopic qualitative relationship     15-39
Preface     15-16
materials and     16-25
results     the discussion 25-32
    32-36
Summary     36-37
References     37-39
second part : TNFα / LTα gene polymorphism and bronchial asthma and asthma severity relationship     39-52
Preface     39-40 the
mATERIALS AND METHODS     40-44
results     44-47
discussion     47-49
Summary     49-50 the
References     50-52
the part : β_2AR gene single nucleotide polymorphism and bronchial asthma and agonists reaction β_2     52-87 < br /> Introduction     52-53
materials and methods     53-68
results     68-74
discussion are found ;   74-82 < br /> Summary     the
References 82-83     83-87 the
review : asthma genetics research progress     87-121
review two : β_2AR gene pharmacogenetics     121-136
abbreviations     136-137
biographical     137-138
thank the     138

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CLC: > Medicine, health > Internal Medicine > Respiratory system and chest diseases > Trachea and bronchial disease > Bronchial disease > Bronchial asthma
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