Dissertation > Excellent graduate degree dissertation topics show

Bronchial asthma molecular genetics research

Author: GaoJinMing
Tutor: LinYaoGuang;QiuChangChun
School: Peking Union Medical College , China
Course: Respiration within the science
Keywords: polymorphism asthma gene HLA-DQ TNFα/LTα polymerase chain reaction β-adrenergic receptor-β2-agonist pedigree genetics
CLC: R562.25
Type: PhD thesis
Year: 2001
Downloads: 283
Quote: 0
Read: Download Dissertation

Abstract


Background and Objective: Bronchial asthma is complex genetic disease, the development of which is determined by host susceptibility and environmental exposure. Asthma is characterized by chronic airway inflammation. HLA class II genes have been identified one of candidate locus for asthma and asthma-related phenotype. HLA class II genes are highly polymorphic, and include DR, DP, and DQ. It has already shown that different HLA products or genes seems to represent risk for or protective factors against in the development of asthma. TNFα is pleiotrophic cytokines which orchestrates immune inflammatory response in the pathogensis of asthma, TNFa gene polymorphism has been shown to be associated with an enhanced transcription of TNFa. LTa gene of being disease marker have been applied for disease-associated study. The β2-adrenergic receptor gene (β2-AR) is on chromosome 5q31-33 within the region that had been linked to asthma. Three of β2-AR gene SNPs affect the function of β2-AR and the response to β2-agonist.The purpose of this study was to investigate the associations between the aboved genes polymorphism and asthma, asthma-related phenotypes by using molecular biological methods.Methods:In 125 Han origin asthmatics and 96 normal healthy controls with same ethnic nearby Beijing region, we analyzed the following items:(1) Asthma questionnaire: symptom, nocturnal wheezing, asthmatic sign score and asthma-specific life quality, allergy, family history, smoking history, et al.(2) The measurement of the TIgE, slgE (specific to d1, d2, mx2) and screening allergen by the method of RAST.(3) Evaluation of pulmonary ventilatory function (FEV1, FEV1%, FEV1/FVC), bronchial responsiveness challenged by Mch (FEV1%>70%), brocho-reversibility

Related Dissertations

  1. Research and Implementation on Knowledge Representation of Gene Regulatory Network,Q78
  2. Research on Combinatorial Regulation of Multiple Transcription Factors,Q78
  3. Cloning and Expression of CHS and CHI Genes and Their Regulation on the Accumulation of Flavonoids in ’Cara Cara’ Navel Orange (Citrus Sinensis Osbeck) and ’Guoqing NO.4’ Satsuma Mandarin (Citrus Unshiu Marcow),S666.4
  4. Chemical Structures and Mechanism Research of Anti-aging Leading Compounds from Natural Products,R285.5
  5. Construction of the Recombinant of HSV-2gD Minotope、 HBsAg、 IL-18 DNA Vaccines and Its Inducing Immune Respons in Mice,R392
  6. CYP2C19 Gene Polymorphism in Patients with Ischemic Cerebrovascular,R743
  7. The Expression Survey of BMP Signalling Pathway in the Human Embryonic Tooth Germ,R78
  8. Cloning and Expression of Growth Hormone Gene in Cobia (Rachycentron Canadus),Q786
  9. Effects of Different Reconciled Corn Oils on Antioxidative Stress, Lipid Metabolism Enzymes, and Abundance of Immune-related Genes of Broilers,S831.5
  10. Polyethylenimine Conjugated Stearic Acid-g-chitosan Oligosaccharide Micelles for Antitumor Gene Therapy,R450
  11. An Approach for Identifying a Plant Resistance Gene Based on the Random Forest,Q943
  12. Functional Analysis of Proteins Encoded by RNA2 of Wheat Yellow Mosaic Virus,S435.121
  13. Comparative Study on Reproductive Biological Characteristics of Helicoverpa Armigera and Helicoverpa Assulta (Lepidoptera:Nuctuidae),S433
  14. Preliminary Study on the Biological Control Potential of the Hypovirus CHV1-CN280 and Functional Analysis of P29,S436.64
  15. Polymorphisms in the Promoter Region of Swine BMP7 Gene and Their Association with Reproductive Traits,S828
  16. Studies on Polymorphisms on Exon and Intron of BMP7 Gene and Their Associations with Reproductive Traits in Pigs,S828
  17. Cloning, Expression and Polymorphism Analysis of BMP4 Gene in Hu Sheep,S826
  18. The Detection of the Virulence-related Gene from Vibrio Alginolyticus and the Study on Preservation Methods,S943
  19. Establishment of the Molecular Identifying System of Curvualria and Application in Difficult Species,Q949.32
  20. Isolation and Identification of Infectious Bronchitis Virus in Henan and the Full Genome Sequence Analysis of Isolated Strains HN104 and HN091,S852.65
  21. Isolation, Identification and Molecular Characteristics of Japane Encephalitis Virus in Henan Province,S852.65

CLC: > Medicine, health > Internal Medicine > Respiratory system and chest diseases > Trachea and bronchial disease > Bronchial disease > Bronchial asthma
© 2012 www.DissertationTopic.Net