Dissertation > Excellent graduate degree dissertation topics show

Studies on a New Ophthalmic Route of Administration System with Puerarin

Author: WuChunJie
Tutor: HouShiXiang
School: Sichuan University
Course: Pharmacy
Keywords: Ophthalmic route of administration system pH triggered gelling Puerarin Borneol
CLC: R283
Type: PhD thesis
Year: 2005
Downloads: 494
Quote: 3
Read: Download Dissertation

Abstract


The tendency of developing new dosage forms through ideal ocular administration is to improve the biopharmaceutical characters and to make drugs enter the target areas more accurately through expected paths. Nowadays, the common problems existing in the Ophthalmic drug delivery system include the short retention time of ordinary eye drops in conjunctival sac due to the fact that dacryma unceasingly excreted in conjunctival sac and is quickly removed through nasal canal, making the drugs difficult to permeate cornea and resulting in a low bioavailability in eyes. Another is the probability of producing pantosomatous adverse effect when the drugs get into gastrointestinal tract after expelling through the nasal canal. Consequently it is of great importance to increase the contact time between drugs and cornea.The consideration to prolong the corneal contact time and improve the corneal permeability of drugs curing the intraocular diseases was introduced in this investigation. Our investigation adopted puerarin as model medicine to prepare pH triggered ophthalmic Gelling for puerarin, in order to enhance the bioavailability of puerarin taken in ocular region. And we also investigated the bases of the proper formulation and practice of borneol, expecting to establish a new ophthalmic drug delivery system of puerarin. Accordingly, we did researches on relative aspects.We investigated hydroxypropyl-β-cyclodextrin (HP-β-CD) on the aqueous solubility, stability and in vitro corneal permeation of puerarin for the purpose of preparing pH Triggered ophthalmic Gelling for puerarin and solving the problems such as color deepening in physic liquor, poor stability and bioavailability, its difficulties in preparing new gel with Carbopol, etc. when solubilizing puerarin.

Related Dissertations

  1. The Study of the Effects of Isoflavones of Puerarin and Daidzein on Bone Metabolism in Ovariectomized Female Rats,R580
  2. The Experimental Study about Protective Effects of Puerarin on Liver of Brain-dead Rats,R285
  3. The Quality Standards. Stability and Pharmacodynamics of Sanjie Zhitong Cataplasm,R286
  4. Dendritic polymer polyamide - the amine - puerarin Composites and its impact on the cornea,R944
  5. The Effect and Potential Mechanism of CP and SP on Hepatoma Carcinoma SMMC-7721 Cell,R735.7
  6. The Effect of Puerarin on the Damage of Mesenchymal Stem Cells Induced by Homocysteine,R285.5
  7. Puerarin volatile oil compatibility with pine needles on rat aortic rings and mechanisms of action,R285.5
  8. Effect of Broneolum Syntheticum or Rhizoma Acori Talarinowii Drugs of Causing Resuscitation by Administering Aromatic Drugs on Penetrating Blood-Brain Barrier of the Naodesheng’s Active Component,R285.5
  9. Dissolution and Pharmacokinetics Study of Components in Ultramicro-Pulverised Powder of Gegen Qinlian Decoction,S853.7
  10. Triamcinolone acetonide combined borneol iontophoresis in the rabbit aqueous humor of pharmacokinetic studies,R965
  11. Puerarin prevention of cerebral vasospasm after subarachnoid hemorrhage Clinical Research,R277.7
  12. Kudzu root isoflavone inhibition of vascular smooth muscle cell proliferation mechanisms of experimental research,R285
  13. Determination of active ingredients of traditional Chinese medicine,TQ460.7
  14. Quality Evaluation of Chongqing kudzu production,R282
  15. Building on the Surface of Titanium of Puerarin Coat and Its Estimate,R783.6
  16. The Effect of Puerarin on the Apoptosis of Cochlea Microvascular Endothelial Cells Induced by Oxygen Free Radical,R285.5
  17. The Effects of Puerarin on Proliferation and Differentiation of Marrow Stromal Cells into Osteoblasts,R285.5
  18. Effects of PAMAM Dendrimers on Ocular Pharmacokinetics of Puerarin,R285
  19. The Absorption Kinetics and Pharmacokinetics of Puerarin and Ferulic Acid in Naodesheng Tablets,R285.6
  20. The Study of Puerarin on Regulation and Control of Aromatase Expression in Endometriosis,R285
  21. Effect on Insulin Resistance Rat Model of Polycystic Ovarian Syndrome Treated with Puerarin,R285.5

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
© 2012 www.DissertationTopic.Net  Mobile