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The Effects of Mirabilis Jalapa on ALT、AST、T-SOD of Alcoholic Liver Injury Rats

Author: YangYiZuo
Tutor: YangJiWu
School: Dali University
Course: Surgery
Keywords: Mirabilis Jalapa Alcoholic liver injury Effect
CLC: R575.5
Type: Master's thesis
Year: 2013
Downloads: 40
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Abstract


Objective: To observe the effects of Mirabilis Jalapa on ALT、AST、 T-SOD ofalcoholic liver injury rats and study the protecting effects on alcoholic liver injuryrats.Methods:40SD Rats were randomly divided to three groups, including model,Mirabilis Jalapa dealing and control groups. Hepatic injury models were establishedby intragastric administration of ethanol. The saline water and ethanol wereadministered intragastrically to the corresponding groups for80continuous days.From the51stday, the Mirabilis Jalapa was administered intragastriclly to accordinggroup for30continuous days. The blood sample and liver were collected in80thday. The concebtrations of aspartate aminotransferase(AST)、 alanineaminotransferase(ALT) and total superoxide dismutase(T-SOD) in serum wereassayed in according to the procedure described in kits. Then the hepatic indexes werecalculated and the pathological changes were observed.Results:1. The activities of ALT were improved in model and Mirabilis Jalapa groupcompared with control group. It indicated the liver injury model leading by ethanolwere established successfully. And the decline of the ALT level in Mirabilis Jalapagroup compared with model indicated the Mirabilis Jalapa can reduce the liver injuryleading by ethanol.2. The activities of AST were improved in model and Mirabilis Jalapa groupcompared with control group. It indicated the liver injury model leading by ethanolwere established successfully. And the decline of the AST level in Mirabilis Jalapagroup compared with model indicated the Mirabilis Jalapa can reduce the liver injuryleading by ethanol.3. The activities of T-SOD were decreased in model and Mirabilis Jalapa groupcompared with control group. It indicated the liver injury model leading by superoxide dismutase were established successfully. And the improve of the T-SODlevel in Mirabilis Jalapa group compared with model indicated the Mirabilis Jalapacan reduce the liver injury through inhibiting superoxide reaction.4. The hepatic index increased in model group and decreased in Mirabilis Jalapagroup compared with control. It indicated that the Mirabilis Jalapa can reduce thehypertrophy changing of liver leading by ethanol injury.5. The hydrophic degeneration and spotty necrosis of liver cells can be observed inmodel group and reduced in Mirabilis Jalapa group.Conclusion: The Mirabilis Jalapa can reduce the liver injury leading by ethanolthrough reducing the level of superoxide reaction to hepatic cells from ethanol.

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Liver metabolic disorders
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