Dissertation > Excellent graduate degree dissertation topics show

The Application Value of Albumin-adjusted Ischemia Modified Albumin Index As An Early Screening Marker for Acute Coronary Syndrome

Author: XuTing
Tutor: JiaYongPing
School: Shanxi Medical
Course: Internal Medicine
Keywords: Acute coronary syndromes Ischaemia modified albumin Albumin-adjusted IMAindex High sensitivity C reactive protein
CLC: R541.4
Type: Master's thesis
Year: 2012
Downloads: 14
Quote: 0
Read: Download Dissertation

Abstract


Background:In the presence of ischaemia,albumin undergoes changes resulting in the formation of ischaemia-modified albumin (IMA). Increased concentration of serum IMA has been found in patients with acute coronary syndrome (ACS). Some reports show that there is a closely relationship between the concentration of IMA and the concentration of serum albumin. Serum albumin concentration is important influencing factor of IMA.So it is recommended that the effects of serum albumin should be taken into the determination of IMA.At present, there is no study on relationship between serum albumin and IMA in China.ObjectiverTo explore the value of IMA to diagnose ACS in prophase;To explore the relationship between the concentration of EMA and the concentration of serum albumin.;To explore the value of albumin-adjusted EMA index to diagnose ACS in prophase,and that when combined the Hs-CRP.Methods:We enrolled60healthy subjects to observe the relationship between the concentration of IMA and the concentration of serum albumin. We also enrolled163consecutive patients(onset of sydroms≤3hours) with symptoms suggestive of acute coronary syndrome (ACS). All patients were devided into either the ACSgroup (n=79) which including32patients with AMI and47patients with UA or other4non-ACS groups (n=84).Determine the IMA, concentration of serum albumin and Hs-CRP of all163patients.Results:The concentration of EMA in ACS group and non-ACS group were70.03±18.20ABSU/mL and52.98±15.29ABSU/mL, P<0.05. In ROC analys, the area under the curve (AUC) was0.764.For an optimum EMA cutoff of58.84ABSU/mL, the sensitivity and specificity were81%and64%, respectively. In60healthy subjects, the mean value of EMA and concentration of serum albumin were50.92±10.25ABSU/mL and44.1±3.10g/L, respectively; The correlation coefficients for EMA and serum albumin was-0.956. In the ROC analysis of the applied albumin-adjusted EMA index, AUC was0.84, and for the ACS diagnosis with an applied cutoff of53.15ABSU/mL, the sensitivity and specificity were89%and68%, respectively. The sensitivity and specificity of albumin-adjusted EMA index combined Hs-CRP for ACS diagnosis were94.5%and71.4%, respectively.Conclusion:the EMA test have superior sensitivity for the early screening of ACS. However, its diagnostic specificity was low; EMA was significantly negatively correlated with serum albumin concentration. Album in-adjusted IMA index is recommended to increase the sensitivity of theACS diagnosis. Albumin-adjusted IMA index combined Hs-CRP can further increase thesensitivity and specificity of the ACS diagnosis.

Related Dissertations

  1. Change and Value of Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Coronary Syndrome,R541.4
  2. Effects of Telmisartan on hs-CRP and HMW-adiponectinin Patients with Essential Hypertension,R544.1
  3. Application and Significance of CISS Classification and TOAST Subtype on Ischemic Stroke (Attach 210 Cases Analysis),R743.3
  4. Ankle-brachial index combined ultra- sensitivity C-reactive protein determination of the value of coronary artery disease,R541.4
  5. Individuals with type 2 diabetes, serum complement factor H, hs-CRP levels and insulin resistance study,R587.1
  6. Relationship between Acute Hyperglycemia and Prognosis in Patients with Acute Myocardial Infarction,R542.22
  7. Platelet-mediated Tissue Factor Expression on Leukocytes in Acute Coronary Syndromes and the Inhibitory Effects of Clopidogrel,R541.4
  8. S100A12 in Coronary Atherosclerotic Heart Disease Expression and Significance,R541.4
  9. Study of Serum Endothelin and High Sensitivity c-reactive Protein in Type 2 Diabetic Patients with Hypertension,R587.1
  10. To Researched the Impact of Rosuvastatin on Adiponectin, Visfatin and High Sensitivity C-reactive Protein in Patients with Metabolic Syndrome,R589
  11. Inflammatory and coagulation factors and CRP1059G / C gene polymorphism and pulmonary thromboembolism associated,R563.5
  12. The Dynamic Variation of Serum Visfatin Level in Acute Coronary Syndrome Patients and Its Clinical Significance,R541.4
  13. Effect of Atorvastatin on the Concentration of Plasma Asymmetric Dimethylarginine in Acute Myocardial Infarction Patients during PCI Perioperative Period,R541.4
  14. Changing and Significance of Plasmic TNF-α and HsCRP in Patients with Acute Myocardial Infarction,R542.22
  15. Constipation in Patients with Essential Hypertension Homocysteine (HCY) and High Sensitive C-reactive Protein (CRP) Levels and Blood Pressure Control,R544.1
  16. A Study on the Correlation Among the Lipid, Cystatin C, High-Sensitivity C-Reactive Protein and the Occurrence, Prognosis of Acute Aortic Dissection,R543.1
  17. Relationship between Serum Cystatin C, High Sensitivity C-reactive Protein and Retinopathy in Patients with Type 2 Diabetes,R587.1
  18. Values of Biomarkers in the Detection of Existence and Severity of Coronary Arterial Atherosclerosis,R541.4
  19. Relationship between Lowerextremity Deep Venous Thrombosis and Highsensitive C-reactive Protein, D-dimer and Homocysteine,R543.6
  20. Relation of Left Ventricular Remodeling to Levels of Serum High Sensitivity C-reactive Protein in Patients with Essential Hypertentsion,R544.1
  21. The Study of the Perioperative Myocardial Protection Effect of the Atorvastatin Intensive Treatment on Cute Coronary Syndrome Patients by PCI,R541.4

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
© 2012 www.DissertationTopic.Net  Mobile