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Neuro-and Mental Development Follow-up Study of Children Born after IVF-ET

Author: LvYuan
Tutor: ZhuYiMin
School: Zhejiang University
Course: Obstetrics and Gynaecology
Keywords: in vitro fertilization and embryo transfer follow-upneurodevelopmental and mental developmental offspring safetyGesell development scales
CLC: R714
Type: Master's thesis
Year: 2012
Downloads: 16
Quote: 0
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Abstract


Objective:The effect of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) on the developing human brain is nuclear. The objective of this study is to evaluate neuro-and mental developmental outcome of children born following in vitro fertilization and embryo transfer (IVF-ET)Methods:A total of85ICSI-conceived children and60IVF-conceived children aged from22months to44.6months were compared with126naturally conceived (NC)controls. Neurodevelopment and mental development was assessed with the Gesell Development Scales.Results:No differences were identified among IVF,ICSI, and NC children with respect to adaption,gross-motor, fine-motor or language.NC children obtained significantly better scores in individual-social development than did children conceived through assisted reproductive technologies.Conclusions:In this follow-up study, IVF, ICSI and NC children show a comparable adaption, motor, language and cognitive development. However, maternal and paternal educational level and raising mode may play different roles in the individual-social development of IVF and ICSI, compared with NC children.

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