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Pretreatment of Ginsenoside-rd Reduces Ischemia-reperfusion Injury in Isolated Rat Hearts by Increasing Coronary Flow

Author: SongChun
Tutor: GaoMingTang
School: Lanzhou University
Course: Pharmacology
Keywords: Ischemia-reperfusion injury Ginsenoside-Rd Coronary flow
CLC: R96
Type: Master's thesis
Year: 2012
Downloads: 43
Quote: 0
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Abstract


Objective: To evaluate the myocardial effects of ginsenoside-Rd in isolated rat hearts and to investigate the potential protective mechanism of ischemia-reperfusion injury. Methods:All rat hearts were isolated and perfused with modified Krebs-Heinseleit buffer (KHB) using the Langendorff preparation. For ischemia-reperfusion trial groups, hearts were treated with ginsenoside-Rd for10minutes after20minutes’equilibrium, followed by30minutes’global ischemia and120minutes’reperfusion. For working heart trial groups, hearts were perfused with KHB containing ginsenoside-Rd for40minutes after20minutes’equilibrium. Both of these two randomized controlled trials were performed using verapamil as positive control. Coronary flow (CF), heart rate (HR), left ventricular end diastolic pressure (LVEDP), left ventricular systolic pressure (LVSP), left ventricular developed pressure (LVDP), and rate pressure product (RPP) were collected to analyze the myocardial effects of ginsenoside-Rd. Results:Ginsenoside-Rd significantly increased the CF in both I/R trial and working heart trial (P<0.05). In I/R trial, it also helped lower the LVEDP and increase the RPP (P<0.05). However, in working heart trial, it showed no significant difference on the HR and LVDP (P>0.05). Conclusion: Pretreatment of ginsenoside-Rd of a middle dose could play a protective role in isolated rat ischemia-reperfusion hearts, by increasing the coronary flow rather than influencing cardiac functional properties previously.

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