Dissertation > Excellent graduate degree dissertation topics show

Triple Antiplatelet Therapy on the Evaluation of Short-term Prognosis of Unstable Angina Pectoris Patients after PCI

Author: HanGaoJie
Tutor: LiYongJun
School: Hebei Medical University
Course: Internal Medicine
Keywords: Load capacity cilostazol unstable angina pectoris percutan-eous coronary intervention high sensitivity C reactive protein myocardialinjury cardiovascular events
CLC: R541.4
Type: Master's thesis
Year: 2014
Downloads: 1
Quote: 0
Read: Download Dissertation

Abstract


Objective: Investigate the triple antiplatelet therapy on the evalua-tion of short-term prognosis of unstable angina pectoris patients after PCI, inorder to supply a clinical evidence for patients who were treated by PCI withpreoperative and postoperative antiplatelet choices.Methods: Selective PCI patients with UAP333cases (male188cases,females145cases) in our hospital were randomly divided into control groupwhich was double antiplatelet treatment therapy group(aspirin and clopidogrel,168cases) and triple antiplatelet therapy group (aspirin,clopidogrel andcilostazol,165cases).The day before PCI the dual antiplatelet therapy groupewas given aspirin and clopidogrel loading capacity300mg, after PCIaspirin was100mg once a day and clopidogrel75mg.While the day beforePCI the triple antiplatelet therapy groupe was given aspirin and clopidogrelload capacity300mg,load capacity for cilostazol was200mg,after PCIpatients in TT were given aspirin100mg once a day,clopidogrel75mg oncea day and cilostazol100mg twice a day.Observing in patients with highsensitivity C reactive protein(hs-CRP), cardiac markers,adverse cardiovas-cular and cerebrovascular events(MACCE)and bleeding events.Results:1There were no obvious differences in clinical characteristics[age, sex,hypertension, diabetes, smoking history, proton pump inhibitors(PPI),theaverage number of vascular lesions,the average number of stent implantationbetween the double groups](P>0.05).2Using hs-CRP as a sign of inflammatory injury, there was no strikingdifference between the two groups before PCI24h(4.67±0.56VS4.63±0.35,P=0.633).The follow-up24h hs-CRP there was a clear difference between the conventional treatment group and the TT group(7.69±0.75VS6.03±0.63,P<0.001).3Detect CK-MB and cTnI after PCI16h, the values were significantlyhigher than the preoperative ones(double antiplatelet group CK-MB:16.80±3.26VS11.30±2.38;cTnI:0.18±0.04VS0.06±0.03;triple antiplatelet groupCK-MB:14.30±2.78VS10.90±3.02;cTnI:0.11±0.03VS0.06±0.02). But after16h triple antiplatelet group compared with dual antiplatelet group CK-MBand cTnI were significantly decreased (CK-MB:16.80±4.3.26VS14.30±2.78,P<0.001;cTnI:0.18±0.04VS0.11±0.03,P=0.017).4After PCI30days the two groups had no serious bleeding to stop anti-platelet therapy in patients. In the dual antiplatelet therapy group there were6cases of a little bleeding and9cases of minor bleeding,while6cases of a littlebleeding and15cases of minor bleeding in the triple antiplatelet group.Therewas no obvious difference between the dule groups(10%VS14%,P=0.538).5Within PCI30days,there were3cases of cardiac death,9cases ofmyocardial infarction,6patients with revascularization and6patients withcerebral stroke in the dual antiplatelet therapy group.While in the tripleantiplatelet group,there were3cases of myocardial infarction and3patientswith revascularization.The incidence of MACCE in the triple anti-plateletgroup was lower than dual antiplatelet therapy group (16%VS4%, P=0.046).Conclusion: Compared with dual antiplatelet therapy, preoperative PCItriple antiplatelet therapy based on the load capacity of cilostazol can reducepostoperative inflammatory reaction and the incidence of MACCE after PCI.At the same time PCI does not increase the incidence of postoperative hemo-rrhage.

Related Dissertations

  1. Association between Microalbuminuria and Cardiovascular Events in the Patients with Primary Hypertension,R544.1
  2. Effects of Intensive Antiplatelet Therapy for Patients with High On-treatment Platelet Reactivity After Coronary Stent Implantation,R541.4
  3. Change and Value of Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Coronary Syndrome,R541.4
  4. The Myocardial Protection Effect of High-Dose Atorvastatin Pretreatment Before Percutaneous Coronary Intervention in Acute Coronary Syndrome,R541.4
  5. Application and Significance of CISS Classification and TOAST Subtype on Ischemic Stroke (Attach 210 Cases Analysis),R743.3
  6. Carrying capacity study of mental planetary drive linear actuator in,TH132.41
  7. Relatinship of the Small, Dense Low-density Lipoprotein with Coronary Heart Disease and the Stenosis of Coronary Arteries,R541.4
  8. Impact of Different Infarct Coronary Artery on Prognosis of Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction,R542.22
  9. Evaiuation of the Value of Treadmill Exercise Test on the Patients of Percutanenous Coronary Intervention to Chronic Total Occlusion,R541.4
  10. The Study on Inclusion Thermodynamics of Different Cyclodextrin Derivatives and Three Drugs,TQ461
  11. S100A12 in Coronary Atherosclerotic Heart Disease Expression and Significance,R541.4
  12. Correlation between Coronary Artery Disease and the Level of Serum Lectin-like Oxidized Low-density Lipoprotein Receptor-1 and Its Polymorphism,R541.4
  13. Study on the Influence of Nursing Intervention on Self-efficacy Level in Patients after Percutaneous Coronary Intervention,R473.5
  14. Protective Effect of Cilostazol on Cerebral Ischemia Reperfusion Injury in Mice and the Influence on the Expression of Bcl-2,R965
  15. The Research on Correlation between Glycosylated Hemoglobin A1c and Acute Cerebral Infarction,R743.3
  16. Glinicalstudy of Early Application of Tirofiban in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention,R541.4
  17. Relationship among Serum Interleukin-6 and High Sensitive C Reactive Protein and Essential Hypertension in Kazakh and Han in Xinjiang,R544.1
  18. The Study on Th1/Th2 Drift and ShuXueTong Injection’s Intervention in UA Patients,R259
  19. Static and Dynamic Analysis on a Double Circuit Intermediate Tower Consisted of Steel Tubes and Angel Steels,TU392.1
  20. Intracellular Concentrations of MMP-9 in Peripheral Blood Leukocytes Increased in Patients with Acute Coronary Syndrome,R541.4
  21. Correlation of Serum Levels of hsCRP and vWF to the Degree and Stability of Coronary Artery Lesion in Patients with Coronary Heart Disease,R541.4

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Coronary arteries ( atherosclerosis ),heart disease (CHD)
© 2012 www.DissertationTopic.Net  Mobile