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The Clinical Significance of Early Analyzing Serum B7-H3from Patients with Acute Pancreatitis

Author: YangZuo
Tutor: ChenWeiChang
School: Suzhou University
Course: Clinical
Keywords: B7-H3 acute pancreatitis ELISA
CLC: R576
Type: Master's thesis
Year: 2013
Downloads: 12
Quote: 0
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Abstract


Objective To analyze the concentration of serum B7-H3from patients with acute pancreatitis(AP), evaluate the relation to severity of AP and study the ability of serum B7-H3to predict severe acute pancreatitis (SAP).Methods From June,2012to January,2013patients diagnosed with AP were included. Serum B7-H3were analyzed in24hours of hospitalization. Blood samples collected from44patients with mild acute pancreatitis(MAP),25with SAP, and30healthy controls were extracted for serum B7-H3. The quantitation of serum B7-H3was performed by sandwich enzyme-linked immunosorbent assay method. Screening performance of the assay was calculated through the receiver operating characteristic (ROC) curve.Results The concentration of serum B7-H3in SAP group,MAP group and the healthy control group respectively were108.34±13.235pg/ml,65.55±9.161pg/ml and54.70±0.483pg/ml. The level of serum B7-H3in patients with acute pancreatitis was significantly higher than in MAP group (P<.001) and healthy controls (P<0.001).The area under the ROC curve (AUC) performed by the serum B7-H3from SAP and MAP groups was0.819(95%CI0.696-0.942). With a cut off value of89.60pg/ml, the overall sensitivity was72.0%and specificity was97.3%.Conclusion Serum B7-H3level is correlated to the severity of acute pancreatitis. It can be used in monitoring the development of acute pancreatitis and may be a potential marker for early diagnosis of severe acute pancreatitis.

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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Pancreatic diseases
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