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Expression and Clinical Significance of Lipoxin A4Receptor and Interleukin-6in Colorectal Cancer

Author: ChengLin
Tutor: CaoShiQiong
School: Huazhong University of Science and Technology
Course: Internal Medicine
Keywords: Lipoxin A4receptor Interleukin-6 Colorectal cancer Immumohistochemical
CLC: R735.34
Type: Master's thesis
Year: 2013
Downloads: 2
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Abstract


Objective: To investigate the expression of lipoxin A4receptor (ALX)and IL-6incolorectal cancer tissue, colorectal adenomas tissue as well as normal colorectal tissue, andanalyze their relationships with clinical pathological factors. To probe into possiblemechanism of lipoxin A4receptor and IL-6in the development and progression ofcolorectal cancer, and to provide certain evidence and guide for prevention, clinicaltreatment and prognosis of colorectal cancer.Methods: To detect expression of lipoxin A4receptor and Interleukin-6in16cases ofcolorectal normal tissue,33cases of adenoma tissue and62cases of tumor tissue usingimmunohistochemical SABC method, respectively.Results: The positive expression rate of ALX in colorectal normal tissue, adenoma andcancer tissue gradually reduces, followed by87.5%,48.49%,24.19%, comparison betweenthe three groups has significant difference (P<0.05); ALX expresses reductivelysuccessively in different differentiated colorectal cancer tissues, but there is no significantdifference (P>0.05); the different expression of ALX has no obvious correlation with theclinical pathologic factors of colorectal cancer (P>0.05);(2) the positive expression rate ofIL-6in colorectal normal tissue, adenomas and cancer tissue increases successively, and theexpression in colorectal cancer tissue, respectively, compared with the normal tissue,adenoma tissue, the difference has statistical significance (P <0.05); expression of IL-6incolorectal cancer tissue has significant correlation with the degree of differentiation, Dukes staging of colorectal cancer (P <0.05), and there is no correlation in patient factors such asage, gender (P>0.05);(3) Expression of ALX and IL-6in the tissue of colorectal cancershows a negative correlation (r=-0.686, P <0.05).Conclusions: ALX in colorectal cancer tissue expresses lower even does not express, thereis no obvious correlation between its level of expression and tumor patients’ clinicalpathologic factors, which prompts that ALX may play an important role in the early phase ofoccurrence and development of the colorectal cancer; Expression of IL-6in colorectalcancer increases, which is associated with the degree of differentiation, Dukes staging ofcolorectal cancer, the expression have a close correlation with the occurrence anddevelopment, invasion and metastasis of colorectal cancer.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
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