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Type 2 diabetes and insulin resistance syndromes , pancreatic β cell function studies

Author: NiuRenXiu
Tutor: ZuoLuGuang
School: Chengdu University of Traditional Chinese Medicine
Course: Chinese medical science
Keywords: diabetes mellitus type 2 type of syndrome insulin resistance index beta cell of islet function index
CLC: R259
Type: Master's thesis
Year: 2008
Downloads: 155
Quote: 3
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Abstract


Objective: To investigate the situation that the insulin resistance being in diabetes mellitus type 2, and discuss the relativity between syndromes with insulin resistance and the function of pancreatic islet. Searching evidence to discern symptoms of diabetes mellitus type 2, and looking for new thought to treat diabetes mellitus type 2 by Chinese traditional medicine.Methods: We referred to the diagnostic criteria of WHO, then divided 84 involved patients into a deficiency of yin with excessive heat syndrome group, a deficiency of both vital energy and yin syndrome group, and a deficiency of both yin and yang syndrome group. Mensurated the data of asting nsuline and fasting blood glucose, and then reckoned the insulin resistance index and the exudation index of pancreatic islet by HOMA expression. The data were analyzed with SPSS13.0. At last, we analyzed the relativity between syndromes with HOMA-IR and HOMA-IS.Results: Comparing the HOMA-IR and HOMA-IS of different groups, we discovered they were descending. The HOMA-IR and HOMA-IS of the patients which in the phlegm and blood stasis syndrome group were distinct larger than those in the non- phlegm and blood stasis syndrome group.Conclusion: 1. The HOMA-IR were different between three groups. Phlegm and blood stasis is the important factor which aggravated the insulin resistance. The quiddity of insulin resistance may be that the phlegm and blood stasis transform to heat.2. The HOMA-IR were different between three groups, and they were descending. In the three groups, the HOMA-IR of patients in the deficiency of yin with excessive heat syndrome group was the largest and the HOMA-IR of patients in the deficiency of both vital energy and yin syndrome group was larger than that in the deficiency of both yin and yang syndrome group.3. For the HOMA-IR and HOMA-IS were different between the three syndrome groups, we could look upon them as the external index to differentiate the syndrome of diabetes mellitus type 2.

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