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Effect of Glucosida Tripterygii Combined with Cyclosporine a on the Anti-rejection in Heart Transplantation Rats

Author: WangJin
Tutor: LiJiLiang
School: Dalian Medical University
Course: Surgery
Keywords: Glucosida Tripterygii(TII) cyclosporine A(CsA) interleukin-2 Heart transplantation Immunosuppression Graft rejection
CLC: R654.2
Type: Master's thesis
Year: 2006
Downloads: 73
Quote: 0
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Abstract


Background:In 1967 Dr. Barnar carried on the 1st human heart transplantation in situ successfully at Cape Town South Africa.Though no more than 5,000 patients have the chance to change their heart per year, the heart transplantation is the best way to treat the severe heart failure. The graft rejection is one of the important factors to obstruct carrying on more heart transplantation. Now most anti-rejection drugs were not specificity to inhibit the body immunologic rejection to transplanted organs.It’s not easy to set down the individual immunosuppressant dose, as the result over immunosuppression or insufficient immunosuppression often occurs in clinic. Over immunosuppression can protect grafts but which decreases the body immunoability and causes many kinds of infections and tumors. On the contrary, the deficiency of immunosuppression makes body reject the grafts and lose function even die. So finding new anti-rejection drugs and ways is still medical research emphases.Objective: After many experiments and clinical trials, people found some traditional Chinese drugs had immunosuppressive ability, but now it could not replace chemical immunosuppressant in clinic. At present there is no drug satisfied because of toxicity and side effects. Many people have tried to use traditional Chinese drugs and immunosuppressant together to prevent and treat graft rejection. This experiment evaluates the synergic anti-rejection effect of Glucosida Tripterygii(TII) combined with cyclosporine A(CsA) with half normal dose via heterotopia rat cardiac allograft by observing the transplanted hearts’beating time and the

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CLC: > Medicine, health > Surgery > Of surgery > Cardiovascular and lymphatic system surgery > Heart
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