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The impact of changes in energy metabolism of the brain tissue of mice salvianolic acid B on cerebral ischemia

Author: WangQiuHua
Tutor: JiangYuFeng
School: Beijing University of Traditional Chinese Medicine
Course:
Keywords: mice energy metabolism cerebral ischemia SalB
CLC: R285
Type: Master's thesis
Year: 2006
Downloads: 181
Quote: 0
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Abstract


Ischemic cerebral injury played an important role in dementia of the old.It was one of main disease dangering human health,because cerebrovascular disease be taken bad rapidly and change quickly.Its many symptoms was discovered and it had vergy high ratio resulting in deformity.According to the data reported by WHO,there was 40 countries that layed the death ratio of zuzhong into anterior third place among 57 counties,especially in which zuzhong in Japan and China had became the most important death cause.Discussing about cerebral tissue injury and treatment afer cerebral ischemia had been very popular in medicinal field.It was largely reported that there is a complex factor and mechanism of pathological change in ischemic cerebral injury.And energy metobolism obstacle was considered as the most early factor of ischemic nerve cell injury.Danshen come from root of labiate Danshen.Its mainly effect was dispelling block,invigorates the blood and passes after and purifies the mind eliminates bothersomely.It was mainly used to treat menstrual discordance,dysmenorrhea,zhengjia agglomeration,chest and abdomen bite,the sore being swollen and painful,emotion dysphoria and insomnia,liver and spleen intumescence,angina.The effect of invigorates the blood and passes after was yet used to treat and prevent cerebral ischemia.Recent many years,modern medicine method,conbination chemistry,molecular biology and cell biology et al technology method were applied to research by the members of Danshen,which obtained a lot of new recognation and experiment results and developed a series of clinic medicament of good curative effect.Water-solubility member salvianolic acid B from salviae miltiorrhizae,especial was regarded greatly by medicinal specilists. Salvianolic acid B had high content in salviae miltiorrhizae and had strong ability to pass blood-brain barrier.So it was a kind of ideal medicne to treat cerebral ischemia. It had been reported that Sal B had strong effects on reducing free radicals and lipid peroxides, The present expriments were to establish blood silt sickness model of cerebral ischemia with hypotension in mice.Then effects of Sal B on energy metabolism obstacle and correlative index was observed.This thesis was composed of literature summarizing and experiment research.Summary1 mainly recommended the research headway about relation between cerebral ischemia and energy metobolism obstacle including cerebral tissue energy metobolism characteristic on normal situation,the relation between cerebral ischemia and mitochodrial injury,pathology physiology mechanism of cerebral tissue injury resulted from energy metobolism obstacle after cerebral ischemia

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