Dissertation > Excellent graduate degree dissertation topics show

Design and Synthesis of a Biomimetic Complex of Heme C_i

Author: YangJuanXia
Tutor: HuChuanJiang
School: Suzhou University
Course: Inorganic Chemistry
Keywords: Heme Ci porphyrin hydrogen bond
CLC: O621.13
Type: Master's thesis
Year: 2011
Downloads: 2
Quote: 0
Read: Download Dissertation

Abstract


Heme Ci is one special heme which has been discovered in cytochrome b6f. It is a five-coordinate high-spin species with OH? or H2O as ligand. It forms hydrogen bonding network with environment which is believed to play an important role in electron transfer and proton transfer. But its function is unclear so far. We are focusing on the model study to provide evidence for the heme Ci’s function in biological system. In this thesis, we have designed and synthesized one model complex, and will present those in three sections.Firstly, the designed precursor （5-（8-ethoxycarbonyl-1-naphthyl）-10,15,20- triphenyl-porphyrin） （H2ENTPP） has been synthesized by a one-pot reaction. The compound was characterized by 1H NMR, Mass spectroscopy, IR, CD and X-ray crystallography. Its crystal was crystallized in a chiral space group, and the molecule has conformational chirality. CD spectroscopy has further confirmed the chirality through KBr pellets. Despite the chirality in the solid state, there was no observable signal when a single crystal was dissolved in solution. It suggests that conversions between conformers of porphyrin are possible and racemization could occur in solution. Secondly, the designed ligand of model compound,（5-（8-carbonyl-1-naphthyl）-10,15,20-triphenyl-porphyrin）, （H2CNTPP） has been synthesized by the hydrolysis of H2ENTPP. The compound has been characterized by 1H NMR, mass spectroscopy, UV-vis spectroscopy, IR and X-ray diffraction.Thirdly, the complex of [Fe（CNTPP）Cl] has been synthesized from H2CNTPP. It has been characterized by 1H NMR, UV-vis spectroscopy and X-ray diffraction. The model complex （most likely [Fe（CNTPP）（OH）]、[Fe（CNTPP）（H2O）2]+） has been synthesized from [Fe（CNTPP）Cl] which is identified by 1H NMR.

Related Dissertations

  1. Synthesis and Properties of Polymeric Dissolved Oxygen Sensor Based on Porphyrin Unit,TP212.2
  2. Theoretical Study of Porphyrins as Sensitizers for Dye-sensitized Solar Cells,TM911.4
  3. Study on the Molecular Face of Hydrides and the Clusters of Hydride,O641.1
  4. Novel Chitosan-based Sydrogels and Their Gelation Mechanism Investigations,O648.17
  5. The Study on the Self-aggregation and Recognition to Biomolecule by the Amino-acid Porphyrin by Synthesis and Characterization,O657.3
  6. Preparation and Properties Research of Porphyrin Derivitives in Dye-sensisized Solar Cell,TM914.4
  7. Research on Energy Storage of F0F1ATPase Motor Based on Robotic Mechanisms,TP242
  8. Fabrication and Analytical Application of L-Ascorbic Acid Biosensor,TP212.3
  9. Sugar-modified porphyrin and phthalocyanine near-infrared fluorescent molecular probes,R914
  10. Synthesis, Structure, Property and Molecule Self-Assembly Study of Supramolecular Compounds Contain N and P,O641.13
  11. Synthesis, Structure and Properties of Pui,TQ334.1
  12. Synthesis of Porphyrin Derivatives & Preparation, Characterization and Application of Porphyrin Self-assemblied Electrodes,O626
  13. Theoretical Analysis on the Hydrogen Bond of Water Cage Cluster （H2O）6,O641.1
  14. Research of Synthesis and Application of Nano-porphyrin,TB383.1
  15. NMR Studies on the Solution Structure of Two β-peptides,O629.72
  16. Synthesis and Application of Polypyridine-bonded Porphyrins,O626
  17. Synthesis of Imidazolporphyrin with Different Chemical Bonds and Study on Their Photoelectric Properties,O626.23
  18. Theoretical Study on the Structure and Cation–anion Interaction of Amino Acid Based Ionic Liquids,O621.13
  19. Theoretical Study on Effects of Hydrogen Bonding on the Ring Stretching Modes of Free and Halogen-Substituted Pyridine,O626.32
  20. Oxidation of Porphyrinogen with Traditional Chinese Medicines and New Methods for Synthesis of Porphyrin Derivatives,R284
  21. Synthesis of Multifunctional Water-soluble Porphyrin,O626

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Organic Chemistry general issues > Theory of organic chemistry,physical organic chemistry > Organic Chemistry Structure Theory
© 2012 www.DissertationTopic.Net  Mobile