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Study on Pharmacokinetics and Pharmacodynamics of Total Alcaloids Extracted from Sophora Flavescens

Author: ChengLiHua
Tutor: WangJianMing
School: Heilongjiang University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: The patch of alcaloids from Sophora flavescens Matrine Oxymatrine HPLC Pharmacodynamics Pharmacokinetics
CLC: R285
Type: Master's thesis
Year: 2002
Downloads: 298
Quote: 1
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Abstract


The main alcaloids in Sophora flavescens are matrine and oxymatrine.In recent years, scientists found and researched on the pharmacological effects of alcaloids. Especially, they paid much attention to anti-arrhythmic effects of matrine and oxymatrine, and studied their mechanism of action. Its injection and oral dosage form have been sold to treat arrhythmia.In this thesis, the patch of alcaloids extracted from Sophora flavescens was made to treat arrhythmia. The experiment result indicated that this dosage form has advantages of sustained-release> long acting^ convenient administration. So the patch has a promising clinical future.By HPLC analytical method in vivo and vitro, pharmacokinetics of TDDS were studied. The results showed that tmax=7.76h, Cmax=9.94ng/mL, AUC=296.45 ( ng/mL) -ho The patch has a desired effect from four hours to twenty-four hours after administration.In addition, rat, guinea pig and rabbit models were used to study pharmacodynamics. The experiment result indicated that the patch has a preventive effect on arrhythmia.

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