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The Studies of the Animal’s Liver Protection on the Yin-chen Compounded Traditional Chinese Medicine

Author: YangLiYing
Tutor: ChenQiang；HuangZhiJian
School: Fujian Agriculture and Forestry University
Course: Animal Genetic Breeding and Reproduction
Keywords: Yin-chen compound preparation baicalin acute liver damage Pharmaceutical kinetics seropharmacology
CLC: S853.7
Type: Master's thesis
Year: 2006
Downloads: 117
Quote: 3
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Abstract


Objective: To study the mechanism of a compound Chinese Medicine Yin-chen compound preparation on the Pharmacokinetics, Pharmacodynamics and Protecting liver. Baicalin of Yin-chen compound preparatio was determined by RP-HPLC assay; Pharmacokinetics of Yin-chen compound preparatio in mice and the Pharmacokinetic parameters were investigated; Protecting action and mechanism were studied of a Yin-chen compound preparation on the acute liver damage CCL4 and in vitro H2O2 liver cell damage; so as to provide scientific basis for its clinic application.Methods:（1） The RP-HPLC assay was invested to determine the content of baicalin in. Yin-chen compound preparation. The chromatogram condition was as follows: Hanbon-C18 column, the mobile phase was a mixture of methanol: water: phosphoric acid （47:53:0.2） with a flow rate of 1 mL/L and detection wavelength at 280nm. Temperature of column is 30℃.Baicalin was quantified with external standard method.（2） Mice of the Kunming were given various Yin-chen compound preparation （5.5g/kg, 11 g/kg, 16.5 g/kg） by i.g for sequence 4 days. A liver injury model was produced in these mice by injecting 0.5% of carbon tetrachloride-earthnut oil solution （0.1mL/10g） into the cervix on the 3rd days of the experiment respectively.. Effects of in-chen compound preparation on the liver histology, Alkaline Phosphatase（ AKP）、 Alanine aminitransperase （ALT ）, Aspartate aminotransferase（AST）、Superoxide dismutase （SOD）、glutanthione peroxidese（GSH-Px） and the concentrations of maleicdialdehyde （MDA） in the CCL4 intoxicated mice were kept under observation.（3） Pharmacokinetics of orally administered at a dose of 16.5 g/kg Yin-chen compound preparation were investigated in mice. Serum concentration of the effective component-baicalin in various times at 0.25, 0.5, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 8.0, 12.0, 14.0, 16.0, 20.0, 24.0h were measured using HPLC and

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Chinese veterinary science > Veterinary Pharmacology
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