Dissertation > Excellent graduate degree dissertation topics show

The Change and Significance of TNF-α and IL-6 in Multiple Injury Patients’ Serum

Author: NingHaiTao
Tutor: LuLi
School: China Medical University
Course: Surgery
Keywords: Multiple injury Tumor necrosis factor alpha Interleukin - 6 Multiple organ dysfunction syndrome
CLC: R641
Type: Master's thesis
Year: 2006
Downloads: 93
Quote: 0
Read: Download Dissertation

Abstract


IntroductionThe multiple injury is a multiple parts and multiple organs injury caused by single wound agent, accompanied by hemorrhea, shock, physiologic function disorder, and even a threat to life. The cytokines have many physiological and pathological functions, which are related with immune and pathology after trauma. We studied the changes of TNF - α and IL - 6 in multiple injury patients’ serum in one week in order to discuss the nosogenesis and significance in clinic and provide the evidence for elevating the remedy level.MethodsThe ELISA method was applied to evaluate the levels of TNF - α and IL -6 in 42 multiple injury patients’ serum and 10 normal persons’ . We observed the changes of TNF - α and IL - 6 after the multiple injury at 1,2,3 ,5 ,7d and compared them with normal persons’. The multiple injury patients were divided into two groups according to with or without MODS, then the levels of the two groups were compared. At the same time, the multiple injury patients were divided into two groups in terms of the survival and the death. And the levels of the two groups were compared either.Results( 1) The levels of TNF - α and IL - 6 in the multiple injury patients’ serum were higher than those of the normal. The difference was significant between the

Related Dissertations

  1. Association of Interleukin-6 Gene Polymorphisms with Susceptibility to Coronary Heart Disease in Asian Populations: a Meta-analysis,R541.4
  2. The Level of IL-17 in Gingival Crevicular Fluid in Response to Orthodontic Force,R783.5
  3. To Explore the Changes of Urinary NGAL, IL-18 and KIM-1 after CAG and PCI, and Evaluate the Implication in Early Diagnosis of CIN,R541.4
  4. An Essential Role for the NLRP3 Inflammasome in Post-Infectious Irritable Bowel Syndreome,R574.4
  5. Obstructive sleep apnea hypopnea syndrome and coronary heart disease relationship,R541.4
  6. Expression of TNF-α, PGE2 and IL-8 in Periodontal Tissues of a Rat Model with Periodontitis Exposed to Hypoxia at Imitational High Altitude,R781.4
  7. The Effect of Hydrochloric Fasudil on Serum Inflammatory Factors and Its Therapeutic Efficacy in Acute Ischemic Stroke Patients,R743.3
  8. Enhanced Anti-tumor Activity by Adenovirus Mediated LIF and IL-24 Co-expression for Tumor Cells and Its Mechanism,R739.4
  9. Construction of Conditionally Replicative Adenovirus Expressing Interleukin-18 and Investigation of Its Antitumor Activity in Vitro,R730.5
  10. Experimental Study (Uterine Morphology and MDA、 IL-2 Levels in the Serum) on the Rat of Chronic Pelvic Inflam-matory Disease with Different Medication of Qingshizhitong Decoction,R285.5
  11. Construction of DNA Vaccine of AG85A Gene of Mycobacterium Tuberculosis and Observation on Immune Response in Mice Induced by Co-Immunization of AG85A Gene Vaccine and Plasmid Encoding Human Interleukin 12,R392
  12. Changes of Monocyte Chemoattractant Protein-2 and Interleukin-12 Level in Serum of Patients after Allogeneic Hemapoietic Stem Cell Transplantation and Their Correlation with Acute Graft Versus Host Disease,R457
  13. Role of Interleukin-18 in Rats with Severe Acute Pancreatitis Complicated with Liver Injury,R657.5
  14. Therapeutic Effect of Locally Injection of Bone-marrow Mesenchymal Stell Cells Decorated by Recombinant Vector of Lentivirus with IL-4 Gene into Inner Ear on Immune-mediated Immune Sensorineural Hearing Loss in Guinea Pigs,R764
  15. TCM Syndrome Type 2 Diabetes and Interleukin-6 and Tumor Necrosis Factor-related Research,R259
  16. A Clinical Study on the Effect of Herbal Fumigation and Washing in Treating Kee Osteoarthritis,R274.9
  17. Effect of Huanglian Jiedu Decoction on Heart Through Regulating Toll-like Receptor 4 in MODS,R285.5
  18. The Influence of Rhizoma Drynariae Total Flavones on β2-adrenergic Receptor, Dopamine-β-hydroxylase and Serum Leptin, Interleukin-6, Prostaglandin E2 in Ovariectomized Rats,R285
  19. Influence of Sinomenine on the Expression of Mast Cells of Joint and the Levels of Serum IL-6 in the Rats of Adjuvant Arthritis,R285.5
  20. Effects of DAA-Ⅰ with Danshensu on the Content of IL-1β and the Gene Expression of ICAM-1 in Experimental Rats with Myocardial Injury Induced by Ischemia,R542.2
  21. Changed Differences of Cognitive Function, and Levels of CRH and IL-1β in the Patients with Primary Insomnia and Insomnia Comorbided with Depression,R749.4

CLC: > Medicine, health > Surgery > Traumatology > Trauma
© 2012 www.DissertationTopic.Net  Mobile