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The Study on Thymopentin Microemulsion

Author: WangJunMin
Tutor: LiuZuoGuang；HeYing
School: Tianjin University
Course: Drug analysis
Keywords: Microemulsion Thymopentin Pseudo- ternary phase diagrams Pharmaceutical dosage forms
CLC: R944
Type: Master's thesis
Year: 2006
Downloads: 321
Quote: 2
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Abstract

Improve the bioavailability and stability, reduce side effects, slow and controlled release dosage form development in recent years focused on targeting agents. Surfactant played a leading role in the development of liquid formulations, such as liposome, cyclodextrin inclusion, the microemulsion is on its basis development of new formulations. The the study Thymopentin model drug study thymopentin microemulsion preparation prescription. Firstly, in accordance with the pharmaceutically acceptable specifications select the appropriate component (water phase, oil phase, surfactant, co-surfactant agent) investigated the phase behavior of the quaternary system, and determine the formation region of the microemulsion. Stirring method were selected different emulsifier / ethanol ratio (Km), and the proportion of oil and water, the preparation of the pseudo-ternary phase diagram of the quaternary system, on the basis of the research phase diagram, selected single caprylic capric acid glycerol acetate / ethanol / trioctanoate capric glycerides / water, prepared as the basic recipe of the microemulsion, the water in oil (W / O) type microemulsion. Thymopentin microemulsion was prepared, and its physical properties, including electrical conductivity, refractive index, and viscosity was measured in the prescription under the condition. In addition, the microemulsion will be prepared to place at different times at 25 ° C and 40 ℃, and pH and the appearance of stability study. The experiments show that the microemulsion prepared at 25 ℃ and 40 ℃ for a month remained stable. Thymopentin was determined by UV method to study the conditions of preparation of thymopentin, results showed thymopentin dubbed the solution kept refrigerated at 4 ℃ 4 days begin to degrade at pH2.5-7.0, for 24 hours or at 60 ℃ 800r/min speed did not cause a change of the activity of thymopentin, was stirred for 1.5 hr at 40 ° C for 40min within the finished microemulsion preparation process does not lead to the destruction of thymopentin. Vivo pharmacodynamic studies to evaluate the microemulsion found the gavage Thymopentin microemulsion can improve immune defect WBC number and percentage of CD3 number close the intravenous Thymopentin the pharmacodynamic effect. This indicates that the preparation of microemulsion in vivo biological effects. The gavage Thymopentin injection does not have this effect. The results of this study show that the microemulsion as the carrier peptide drugs by oral administration is feasible, although the absorption mechanism is to be further explored, but the broad market prospects, and has good application development value.

The Study on Thymopentin Microemulsion

Abstract

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