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Study on the Synthesis Process of Amprolium Hydrochloride

Author: LvMinZhu
Tutor: YangLiRong
School: Zhejiang University
Course: Chemical Engineering and Technology
Keywords: Amprolium Anticoccidiosis Drug Synthesis
CLC: TQ463.53
Type: Master's thesis
Year: 2007
Downloads: 171
Quote: 0
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Abstract


The synthesis of Amprolium Hydrochloride, a widely-uesd anticoccidiosis drug, has been investigated. Amprolium was successfully prepared via 4 steps by using commercially-available butyronitrile and acylonitrile as starting materials. Firstly, one of the important intermediate compounds, named butylamidine hydrochloride, was prepared by reacting butyronitrile with methanol and amminia with excellent yields. Another intermediate, named α-methoxymetyl-β-methoxylacrylonitrile, was synthesized by reaction of arcylonitrile with methyl formate and methylation with dimethyl sulfate. Then, 4-amino-(5-methoxy)-2-propyl pyrimidine was prepared by using the two intermediates as materials. Finally, the product was obtained by reacting 4-amino-(5-methoxy)-2-propyl pyrimidine with 2-picoline and certified by ~1HNMR, IR etc.

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CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug > Heterocyclic compounds drugs > Five section heterocyclic
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