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Preparation and In-vitro Release of Biodegradable Erythromycin-loaded Microspheres

Author: JiangDan
Tutor: ChenXia
School: Jilin University
Course: Biochemistry and Molecular Biology
Keywords: Gelatin Erythromycin Emulsion crosslinking method Curing agent Bienzyme method Microspheres
CLC: R943
Type: Master's thesis
Year: 2007
Downloads: 208
Quote: 0
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Abstract


The thesis biodegradable gelatin as a carrier , using the emulsion crosslinking prepared gelatin microspheres , the first effects of the curing agent added roundness and dispersion of microspheres , and gelatin solution was studied by orthogonal experiments concentration , stirring speed , water and oil phase ratio of the particle size of the microspheres . The results show that the gelatin microspheres, prepared under the process in this article having a uniform particle size , into a ball of high characteristics, and smoothing the surface of the microspheres , and the average particle diameter of 13.72μm . Prepared gelatin microspheres in vitro degradation studies , preliminary study in vitro degradation mechanisms . On this basis , the side effects of erythromycin on gastrointestinal irritation , gelatin -embedded to erythromycin erythromycin - gelatin microspheres were prepared , the average drug entrapped was 27.2% . In a simulation of the fluid environment of the PBS release system has a good release effect , sustained release of the drug can be maintained for more than 10 days , and using dual enzyme hydrolysis system to simulate the human gastrointestinal tract environment Erythromycin gelatin microspheres as an oral dosage form the release characteristics of the digestive tract .

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CLC: > Medicine, health > Pharmacy > Pharmacy > Pharmaceutics
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