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Background and Purpose: Kit gene mutation and PDGFRA gene mutations in the pathogenesis of gastrointestinal stromal tumors (GIST), and both mutations is mutually exclusive. Kit gene and corresponding protein product Kit (CD117) is more consistent, and PDGFRA research CD117 relationship between a relatively small and a large difference. In this study, 36 cases of GIST, CD117, PDGFRA immunohistochemistry and clinicopathological study on the relationship between the expression of PDGFRA in GIST as well as the relationship between CD117, PDGFRA and CD117 and clinical pathological factors. Methods: Department of Pathology, the First Affiliated Hospital of Zhengzhou University, 2004-2006, 36 cases with complete data, clear pathological diagnosis of GIST specimens. Morphology was observed first by HE staining of specimens, histological type, grading and biological behavior; tumor expression of CD117, PDGFRA detected by immunohistochemistry (SP method); using Fisher's exact test for each protein. expression, clinicopathological factors and the biological behavior of the statistical analysis. Results: (1) epithelial cell type in 36 cases of GIST histological morphology: spindle cell type in 28 cases (77.8%), 5 patients (13.9%), other types of 3 cases (8.3%). (2) in 36 cases of GIST, CD117, PDGFRA protein expression rate was 77.8% (28/36), 47.2% (17/36). CD117 positive expression in 28 cases of GIST PDGFRA positive in 11 cases; CD117 negative expression of eight cases of GIST PDGFRA positive six cases. PDGFRA positive expression rate of CD117 positive and negative GIST difference was not statistically significant (P> 0.05). (3) CD117 expression and patient gender, tumor site, histological type and invasion risk was not statistically significant (P> 0.05). (4) PDGFRA expression in patients gender, tumor site and invasion risk was not statistically significant (P> 0.05), but the difference was statistically significant (P <0.05) histological type. Conclusion: (1) PDGFRA and CD117 expression does not have a mutual exclusivity, PDGFRA expression of CD117 negative GIST with CD117-positive GIST no significant differences. Diagnostic indicators the PDGFRA become CD117 negative GIST pending further study. (2) CD117 expression and patient gender, location, histological type and invasion risk are unrelated, CD117 can not be used as the organization the typing judgment GIST indicator of the degree of malignancy. (3) PDGFRA expression of the patient's gender, location and invasion risk are unrelated, PDGFRA higher rate of positive expression in the epithelial cells of GIST. PDGFRA not determine indicators of the degree of malignancy of GIST.
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