Dissertation > Excellent graduate degree dissertation topics show

Study on Transforming Growth Factorβ1 and Estrogen Receptor and Collagen Ⅰ、Ⅲ in Pelvic Floor Tissues for Postmenopausal Female Stress Urinary Incontinence

Author: SuHui
Tutor: WangLuWen
School: Zhengzhou University
Course: Obstetrics and Gynaecology
Keywords: Stress Urinary Incontinence Pelvic organs prolapse Pelvic floor Estrogen Receptors Transforming Growth Factorβ1 collagen I、III
CLC: R694
Type: Master's thesis
Year: 2007
Downloads: 136
Quote: 0
Read: Download Dissertation

Abstract


Background and Objective:Stress urinary incontinence （SUI） is a common disease that affects seriously the quality of life of middle and old age women.20% of middle and old age women suffer from different degrees of SUI. Pelvic organs prolapse （POP） which has close relationship with SUI is common clinical gynecologic problem also. The pathophysiology is not clear now. More postmenopausal femal suffering this disease,it suggestive that there is relationship between estrogen and SUI. Estrogen must combine with estrogen receptor ,if it work well .Recently there are lots of studies show collagen is very important in SUI. There are less collagen in pelvic tissue of SUI. Transforming Growth Factor-β1 is a important factor in forming fibre. It help tissue grow more collagen The aim of this study is to explore the relationship between estrogen receptor and transforming growth factorβ1 and collagen I、III with the occurrence of stress urinary incontinence（SUI）through analysis on estrogen receptor and transforming growth factorβ1（TGF-β1） and collagen I、III in paries anterior vaginase.Materials and Methods:1. Materials:SUI group—30 patients,postmenopause;POP group—28 patients, postmenopause ;normal group—30 patients, menopause. All of them were not accepted endocrine therapy in three months and agree with clinical diagnostic levels.2. Methods: The biopsy specimens in anterior vaginal wall were obtained from 88 subjects undergoing hysterectomia, tension-free vagina tape（TVT）, Burch procedures, who were assigned in to control, pelvic organ prolapse （POP） and SUI groups. The histological structures in paries anterior vaginase were examined with routine HE staining. ER and TGF-β1 and collagen I、III in structures in paries anterior vaginase was evaluated by immunohistochemical staining.Results: 1. ER positive staining in paries anterior vaginase was 1.66% in SUI group, 1.73% in POP group, 2.64% in contral group , respectively. It was significantly lower in SUI group and POP group than that in control group（p<0. 05） ,and it wasn’t significantly lower in SUI group than that in POP group （p>0. 05） rate.2. TGF-β1 positive staining rate in paries anterior vaginase was 20.00% in SUI group, 14.30% in POP group,93.33% in contral group ,respectively. It was significantly lower in SUI group and POP group than that in control group（p<0.05） ,and it wasn’t significantly lower in SUI group than that in POP group （p>0.05） rate.3. Collagen I positive staining luminance in paries anterior vaginase was 98.62±0. 28 in SUI group, 98.15±0. 40 in POP group, 100.03±0. 27 in contral group , respectively. It was significantly lower in SUI group and POP group than that in control group（p<0.05） ,and it wasn’t significantly lower in SUI group than that in POP group （p>0.05） rate, collagen HI positive staining luminance in paries anterior vaginase was 98.46±0.35 in SUI group, 98.23±0.18 in POP group, 100.12±0.42 in contral group , respectively. It was significantly lower in SUI group and POP group than that in control group（p<0.05） ,and it wasn’t significantly lower in SUI group than that in POP group （p>0.05） rate.4.There is direct correlation between ER and Collagen I、III.Conclusions:1. ER decline in anterior vaginal wall of postmenopause SUI patients. ER decline cause anterior vaginal wall atrophic and anterior vaginal wall can not support urethra helping it keeping normal. ER decline correlated with SUI in postmenopause patients.2. TGF-β1 decline in anterior vaginal wall of postmenopause SUI patients. TGF-β1 decline cause anterior vaginal wall atrophic and anterior vaginal wall can not support urethra helping it keeping normal. TGF-β1 decline correlated with SUI in menopause patients.3. Collagen I、III decline in anterior vaginal wall of postmenopause . SUI patients. Collagen I、III decline cause anterior vaginal wall atrophic and anterior vaginal wall can not support urethra helping it keeping normal., Collagen I、III decline correlated with SUI in menopause patients.

Related Dissertations

  1. The Perineal Sonography in Diagnosis and Analysis of 30 Cases of Stress Urinary Incontinence,R445.1
  2. Pregnancy and childbirth and incontinence related factors,R694.5
  3. The Study on the Relation between the Serum Relaxin Levels and the Pelvic Floor Dysfunction,R711
  4. Effects of 5-Aminolevulinic Acid in the Photodynamic Photorejuvenation Therapy of Intense Pulsed Light,R751
  5. Clinical Effects, Imaging Study and Treatment of TOT Procedure Combined with Modified Pelvic Floor Reconstruction on Female Stress Urinary Incontinence,R699.7
  6. Middle-aged and Old Women with Stress Urinary Incontinence in the Community of Shanghai: Cross-sectional Study and Intervention Study,R473.2
  7. The Effect of Yinchenhao Decoction on Expression of CTGF and TGF-β1 in the Kidney Tissues of Rats Suffering from Chronic Renal Failure Which Caused by Deniae,R285
  8. Cognitive intervention for female urinary incontinence clinical efficacy studies,R694.54
  9. Detect and Analyze on the Content of Type Ⅰ and Type Ⅲ Collagen in Tissue of Abdominal Wall in Adult Patients with Inguinal Hernia,R656.2
  10. A Study on Collagen Protein Degradation Mechanism by Matrix Metalloproteinases–2 of Adults Inguinal Hernia,R656.2
  11. Experimental Study of Differentiation of Rat Bone Marrow Mesenchymal Stem Cell into Fibroblasts in Vitro,R329
  12. In Vitro Experiment of the Effect of Free SiO2 Dust to Rat Circulating Fibrocytes,R114
  13. Study the Relationship between Serum Levels of Silicon and Collagens in Rats Exposed to Silica at Different Stages,R563.9
  14. The Study on Influence of Pregnancy and Delivery on the Function of the Pelvic Floor by Ultrasound Imaging and Pelvic Floor Muscle Strength,R445.1
  15. The Study of the Effects of FFNT-5 on Renal Fibroblasts in UUO Model Rats,R692
  16. Effect of Serum of Total Flavonoids of Litsea Coreana Level on Tgf-β1-induced Rat Hepatic Stellate Cell and Its Mechanism,R285.5
  17. Effect of Vaginal Delivery on Pelvic Floor Muscles Function and Clinical Application Study of Postpartum Rehabilitation,R49
  18. A Study on the Biological Effect of Intermittent Cyclic Stretching Tension on Tissue Engineered Tendon in Vitro,R318.01
  19. The Effect of Aminophylline on Transforming Growth Factor-β1 and Collagen in Rat Models of COPD,R965
  20. The Applications of Pelvic Anatomy Analysis by Dynamic and Static MRI Subsequence in Pelvic Reconstruction Surgeries,R445.2
  21. Three-dimension Imaging Study on Anatomy and Function of the Levator Ani with Pelvic Floor Dysfunction,R445.2

CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Bladder disease
© 2012 www.DissertationTopic.Net  Mobile