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Systemic lupus erythematosus may invade the whole body multi-system autoimmune disease, often the patient serum autoantibodies appears as the standard, is one of the incurable diseases with common clinical the clinical no particularly effective method of treatment. The etiology of this disease is not yet clear, and is generally believed that genetic, viral infection, taking certain medications, ultraviolet radiation, endocrine disorders, and other factors related to. There are three commonly used treatments: pure Western medicine therapy, Chinese medicine therapy Integrative Medicine Law. Pure Western medicine therapy large number of long-term use of hormones and immunosuppressive agents, are inevitably followed by side effects and complications. Chinese medicine for the treatment of SLE, because of its curative effect be sure, more and more are currently being used in clinical. Lupus Granule compound preparations made by the broad bean root, Panax, Ligustrum lucidum, Gentiana, wind 17 herbs, blood circulation, Qufeng, heat pain and other effects, mainly for systemic The treatment of lupus erythematosus. The purpose of this project is to study of lupus flat granules on the treatment of lupus-like mice, inhibition of allergic, anti-inflammatory, antipyretic, and analgesic effects. 1. Experiment by Kunming mice by intraperitoneal injection of Escherichia coli lipopolysaccharide (2.5 mg / kg), obtained with human clinical characteristics similar incentives, similar in nature to the murine SLE model. Lupus level and select granules of high, medium and low dose study, sera from mice and morphological detected by different doses of drug action. The results showed that the lupus flat granules is effective for the treatment of systemic lupus erythematosus indeed make autoantibodies weakened, and joints, liver, kidney, has a protective effect. 2. Arthus reactions and passive cutaneous anaphylaxis experimental study showed that lupus flat granules the allergy has good inhibition and immunomodulatory effects. 3. Anti-inflammatory, antipyretic, analgesic experiments prove lupus flat granules can prolong the pain caused by hot plate method in mice pain threshold, p-xylene-induced ear edema in mice significantly inhibited, and can significantly reduce the large Rat 2,4 - dinitrophenol induced fever when the body temperature, Granule for lupus that has anti-inflammatory, antipyretic and analgesic effects. The experimental results show the efficacy, mechanism of action may lie in improving immune function of lupus level granules for the treatment of systemic lupus erythematosus. The results of this study for lupus flat particles development has laid a solid foundation for a new treatment of systemic lupus erythematosus drug.
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