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The Soft Capsule Yang Kun Eucommia Eucommia seed total glycoside extracted from Eucommia seed made ??of soft capsules . To of Eucommia Yang Kun soft capsule developed into new drugs of traditional Chinese medicine , pharmacology and toxicology investigation by animal experiments carried out on the of Eucommia Yang Kun soft capsule . In this paper, a method of pharmacology and toxicology studies of Eucommia Yang Kun soft capsule on the general behavior of the mice , the spirit of spontaneous activity , coordinated movement through the system , the digestive system ; anesthetized dogs , such as blood pressure , heart rate , circulatory system and respiratory frequency and amplitude, breathing the impact of the system ; observed after 9 months of Beagle dogs orally administered long - term toxicity and the extent of poisoning symptoms first appeared , and the severity of target organ toxicity , its recovery and development . Determine the dose of the non - toxic reaction . Reference to the preparation of safe dose . Under our experimental conditions , Eucommia Yang Kun soft capsules had no significant effect on the general behavior of the mice and coordination of movement ; promote the movement of the mouse intestinal , no significant effect on the moisture content of the small intestine . Eucommia Yang Kun soft capsules in anesthetized dogs systolic blood pressure, diastolic blood pressure , mean pressure , heart rate , myocardial tension time index , respiratory rate , and breathing rate had no significant effect . Beagle dogs were administered orally safe dose of 400mg/kg. Beagle dogs to growth and development , organ index , hematological indices , biochemical parameters , changes in urine , heart rate showed no abnormality . The experiment conducted a safety evaluation of the toxicity of Eucommia Yang Kun soft capsule . The general pharmacological study period found that the respiratory, circulatory , central nervous , digestive special effects . Not in clinical employing these experiments , so the choice of experimental animals for evaluation. So as to achieve the real objective evaluation of the safety of Eucommia Yang Kun soft capsule long-term medication . Provide a true and reliable experimental data for the clinical treatment and medication safety . With a dose of the preparation of the reference .
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