|
Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic inflammatory joint tissue sexually transmitted diseases into the main manifestation of systemic autoimmune diseases , chronic diseases is a serious threat to public health in the current worldwide . The range of its etiology , pathogenesis is complex . In this study, through the establishment of a variety of animal models , anti-inflammatory and analgesic antipyretic effects observed Datong-Qinhuangdao straminea , decoction , and to explore its anti-inflammatory mechanism . 1 . Experimental study of anti-inflammatory experimental study of the experiment through the use of complete Freund's adjuvant -induced rat paw edema , xylene-induced mouse ear edema , acetic acid-induced mouse peritoneal capillary permeability and rat granuloma impact reveal the Daqin straminea Decoction has a certain anti-inflammatory effects , and compare the results with the control group , there were significant differences . 2 . Analgesic Experimental study of the present study, mice acetic acid writhing body and hot plate method analgesic effect observed Datong-Qinhuangdao straminea , decoction , and compare the results with the control group , there were significant differences , suggesting the Daqin straminea Decoction has analgesic effect . 3 . The antipyretic experiment to study the experiment 2,4 - dinitrophenol -induced fever , antipyretic effects observed Datong-Qinhuangdao straminea , decoction , compared with the control group until the end of 150 minutes , 20 minutes from pyrogenic , each dose groups have different levels of cooling effect , the difference was statistically significant , indicating that the the Daqin macrophylla decoction antipyretic effect . 4 . The anti-inflammatory mechanism of the experiment through the use of complete Freund's adjuvant -induced disease model of rheumatoid arthritis on rat spleen and thymus weight index and serum IL -1beta , TNF - alpha , VEGF the content determination to explore anti-inflammatory mechanism of of Datong-Qinhuangdao straminea , decoction , compare the results with the model group , there were significant differences show that the Daqin straminea Decoction can play an immunosuppressive effect by reducing the rat spleen and thymus weight index ; by reducing the proinflammatory cytokines IL -1beta TNF - alpha content to suppress the development of inflammation , at the same time , by reducing the amount of VEGF in the blood to inhibit angiogenesis and pannus formation. In summary, the experimental study on the the Daqin macrophylla decoction anti-inflammatory and analgesic antipyretic effect of its anti-inflammatory mechanism , revealing the drug has anti - inflammatory and analgesic antipyretic and suppress immune function , and clinical application of experimental basis .
|