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Research of a Cerebral Oxygenation Monitoring Technology Using Near-Infrared Spectroscopy

Author: WuXin
Tutor: SunJinZuo
School: Harbin Institute of Technology
Course: Instrument Science and Technology
Keywords: Near Infrared Spectroscopy Spatial resolution Oxygen concentration Organizational model
CLC: R318.51
Type: Master's thesis
Year: 2010
Downloads: 79
Quote: 2
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Abstract


The human brain as an organ of the body's central nervous system, domination and directing the human body all the physiological activities. Human brain tissue blood flow and oxygen consumption are very large. Brain tissue when a particular region in the active, the local blood volume will increase and increase the amount of reaction the degree of activation. Changes in the amount of brain tissue blood volume as indicators of brain functional activity. Using near infrared spectroscopy to monitor brain oxygen changes, non-intrusive, real-time, continuous, high temporal resolution, cheap, easy to operate, and many other advantages, the activities in the understanding of brain function, the positioning of regional brain function and clinical brain protection The field has broad application prospects. This paper first introduces the basic principle of the optical properties of biological tissue and biological tissues optical correction Lambert - Beer law based on the steady-state spatial resolution theory, research and design a set of multi-wavelength multi-channel near-infrared spectroscopy oxygen monitoring system . The design of this project oxygen monitoring systems, including sensors, analog circuits, digital circuits, and the host computer system module. Sensing probe with integrated multi-wavelength LED as the light source, and choose low-noise, high-gain the OPT101 as light detector, designed more than the distance of the light source and detector probes. The hardware circuit microcontroller C8051F020 as the core, to achieve control of the light source driver chip A / D acquisition, data processing, LCD, key control, serial communication functions. PC control system to achieve the serial communication, data storage, real-time display of oxygen saturation functions. A series of experimental tests on the system. , Making the optical characteristics close to the solid model of the human tissue in vitro tissue model experiments. Monolayer tissue model experiments prove the stability and effectiveness of the system. Multi-layered tissue model experiments to simulate multi-layered organizational structure of the head, the outer layer of the cerebral oxygen test results provide a theoretical basis for the correction of the measurement results in the body monitoring. The human forearm blocking Experimental results show exactly the same trend with the organization of the system detected changes in oxygen saturation in the blood oxygen concentration trend. Finally, the experimental results of brain function description, the system monitoring the optical density change to reflect changes in cerebral blood volume, to monitor the function of the brain region activity. Experimental testing to verify the oxygen monitoring methods of the near-infrared spectrum with a wide range of research on the cognitive activity of the human brain.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > Other branches of biomedical engineering > Light,laser biomedical
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