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Five kinds of commonly used drugs and eight kinds of transfusion compatibility stability study

Author: MaAiLing
Tutor: SunLiXin;ChenXiaoHui;BiKaiShun
School: Shenyang Pharmaceutical University
Course: Pharmaceutical Analysis
Keywords: Amoxicillin Omeprazole Tinidazole Ampicillin sulbactam Ornidazole Infusion Compatible Stability HPLC
CLC: R942
Type: Master's thesis
Year: 2008
Downloads: 51
Quote: 0
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Abstract


Amoxicillin, omeprazole, tinidazole drugs used in combination (triple therapy) is a common clinical treatment of peptic ulcer program, the ampicillin sulbactam ornidazole two drug associated with the clinical treatment of disgust oxygen infection common program. This study examined the five kinds of drugs and eight kinds of infusion compatibility stability, effects of amoxicillin sodium, omeprazole sodium and tinidazole three kinds of drugs in sodium lactate Ringer's Injection (SLR), compound sodium lactate Yamanashi Compatible Stability of alcohol injection (SLS), and ampicillin sodium sulbactam sodium and ornidazole sodium chloride injection Stability of Compatibility, designed to provide a reference for clinical treatment. This study established HPLC determination of sodium amoxicillin, omeprazole sodium, tinidazole, ampicillin sodium sulbactam sodium and ornidazole azole drugs; developed for the simultaneous determination of amoxicillin sodium, Ogilvy omeprazole sodium and tinidazole drug content HPLC method: ODS column (4.6 mm × 150 mm, 5 μm, Dalian, Delta Company), a mobile phase of acetonitrile-pH7.6 phosphate buffer solution (30: 70), set the single-pump flow rate gradient elution, detection wavelength 285 nm, the column temperature was room temperature; establish a HPLC method for simultaneous determination of ampicillin sodium and sulbactam sodium and ornidazole drug content: ZORBA * SB-C 18 column (4.6 mm × 250 mm, 5μ, Agilent), a mobile phase of acetonitrile-0.02 mol L -1 phosphorylation of potassium dihydrogen solution (15:85), set the single-pump flow rate gradient elution, detection wavelength 230 nm, the column temperature was room temperature; content examine the compatibility of the drug, and the combination of appearance, pH value, insoluble particulate investigation index compatibility stability of the drugs. The results showed that: amoxicillin sodium compound electrolyte injection of glucose R2A compound electrolyte glucose the R4A injection fluid, 1h compound electrolyte glucose M3A injection infusion compatibility, stability, and stability with the other five kinds of infusion compatibility within 6h; Austria 6h infusion compatibility of omeprazole sodium SLR, SLS 2 within the stable, and the other six kinds of infusion compatibility instability; ampicillin sodium sulbactam sodium compound electrolyte glucose the M3A injection, compound electrolyte glucose the M3B injection fluid, compound electrolyte glucose the R4A injection three kinds of infusion compatibility 1h stable, with the other five kinds of infusion compatibility within 6h stable; tinidazole, ornidazole and transfusion compatibility within 6h after stable; amoxicillin sodium, Ogilvy \u0026 Mather omeprazole sodium and tinidazole combination SLR SLS 6h after compatibility and stability; 6h stability ampicillin sodium sulbactam sodium and ornidazole sodium chloride injection compatibility. This study examined the degradation of omeprazole sodium acid infusion, semi-preparative liquid separation and preparation of the degradation products of omeprazole sodium acid infusion, the degradation products UV scan found that the the compound two larger absorption peaks at 214nm and at 300 nm; Thermo Finnigan LCQ Advantage mass spectrometer for mass spectrometric detection, the ion source is an electrospray ionization source (ESI source), the positive ion mode detection, the results show a molecular weight of 329. One of the degradation products of omeprazole sodium of the compound's physical and chemical properties and spectral data reported in the literature is consistent with literature reports, we concluded that the compound 5 - methoxy-2 - [(4 - methoxy-3 , 5 - dimethyl-2 - pyridyl) methylthio-1H-benzimidazole.

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