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Clinical Research of Guillain-barre Syndrome

Author: WangLe
Tutor: DuYanHui
School: Ningxia Medical University
Course: Neurology
Keywords: Guillain - Barre syndrome Clinical features Immunoglobulin Plasmapheresis Treatment time
CLC: R745.43
Type: Master's thesis
Year: 2010
Downloads: 34
Quote: 0
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Abstract

Objective: 201 cases of GBS retrospective analysis of clinical data to explore the clinical characteristics of the disease and IVIG, PE, of CS treatment effect, which provide help for early diagnosis and proper treatment. Materials and Methods: A retrospective analysis of a clear diagnosis of our hospital from January 1995 - January 2010, 201 cases of hospitalized cases of GBS are in line with the Chinese Journal of Psychiatry 1993 Editorial Board developed GBS diagnostic criteria. EMG results are divided into the axonal damage groups and demyelinating damage group, some of the clinical features and efficacy of the two groups were compared. Divided into the plasmapheresis treatment group, the immunoglobulin therapy group, hormone therapy group divided into light, medium and heavy-duty according to the severity of disease; different drugs; According to two weeks after treatment, clinical recovery two markedly effective, effective and ineffective group comparison efficacy between the different treatment groups in the same condition conditions; given different treatment, the incidence of the disease is to improve the time there is no difference; the immunoglobulin therapy group, plasma exchange treatment group time sooner or later, and the prognosis. Results: In 201 patients, male 67.16%, and 32.84% of women. The age of onset is 15-44 years old, the highest incidence in summer, the precursor of factors, mostly upper respiratory tract infection, accounting for 64.18%. 95.0% of patients with movement disorders, the average incidence of 8 ± 5.40 days to reach the disease peak. Often the first symptom limb weakness 48.26%, tendon reflexes accounted for 75.12%, 55.72% of the patients with sensory disturbances, 52.74% of the patients with brain damage, 43.28% of the patients with damage to the autonomic nervous performance, 28.86% of respiratory muscle involvement , 13.43% of patients requiring endotracheal intubation or tracheostomy. Cerebrospinal fluid protein - cell separation, accounting for 96.41%, 87.80% electrical nerve conduction studies in patients with abnormal results. The axonal damage group diarrhea (P lt; 0.05), and demyelinating group more sense for more than (P lt; 0.05) were statistically significant differences; compare the efficacy of group of axonal damage and demyelination group No statistically significant difference (P gt; 0.05). Immunoglobulin group plasmapheresis group under the same condition the efficacy There was no significant difference (P gt; 0.05), in the different treatment periods given immune globulin or plasma exchange, were found in P lt; 0.05, the earlier the treatment, The results were better, statistically significant. For patients with mild disease medium, hormone and immune globulin significant efficiency significantly different (P lt; 0.05); hormones and immunoglobulin heavy patients, the efficiency difference (P lt; 0.05); For medium-sized patients, hormone efficiency immunoglobulin no difference (P gt; 0.05). Plasma exchange group and immunoglobulin group from the onset to the time of symptom improvement was no statistical difference (P gt; 0.05) than the hormone group improved (P lt; 0.05). Conclusion: The group of 201 cases of GBS patients with a variety of clinical manifestations, cerebrospinal fluid and electrical nerve physical examination results reported in China. Given immunoglobulin, plasmapheresis treatment, significant effects were good, and can shorten the course of the disease, and the earlier the treatment, the better the prognosis. Efficacy of immune globulin was significantly higher than the hormone, hormone and the general treatment of undifferentiated, and the effect of the hormone in the treatment of patients with GBS may GBS as the natural outcome of a self-limiting disease caused.

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