Dissertation > Excellent graduate degree dissertation topics show

The Research of an Animal Model on Alcohol-induced Osteonecrosis in Short-term

Author: TieWeiBin
Tutor: WangYiSheng
School: Zhengzhou University
Course: Surgery
Keywords: Horse serum Alcohol Osteonecrosis of the femoral head Animal models Short term Rabbits
CLC: R681.8
Type: Master's thesis
Year: 2009
Downloads: 20
Quote: 0
Read: Download Dissertation

Abstract


Background: With the increasing global consumption of alcoholic beverages , alcoholic osteonecrosis of the femoral head in patients is increasing year by year . Alcoholic femoral head necrosis is more common in young and middle-aged male chronic alcoholism , higher morbidity , serious impact on the patient's ability to work and quality of life , has aroused extensive attention of clinicians . With the gradual deepening of alcohol induced femoral head necrosis prevention work to establish an ideal animal model is particularly important . Objective: To investigate ethanol feeding on the rabbit femoral head horse serum sensitization conditions . Methods: 48 male rabbits were randomly divided into four groups , each 12 . Group A: intravenous horse serum 10ml/kg interval of three weeks , the second injection of the same amount of horse serum , two weeks after gavage given saline 10ml / (kg · d). Group B : do not give the horse serum , Group A time synchronization gavage given the potent liquor (volume fraction of 46% ethanol ) 10 ml / ( kg · d ) . Group C: intravenous horse serum 10ml/kg interval of three weeks , the second injection of the same amount of horse serum , two weeks after gavage given potent liquor (volume fraction of 46 % ethanol ) 10 ml / ( kg · d ) . Group D: Group A time synchronization the gavage method only given saline 10 mL / ( kg · d ) . Animals in each group were sacrificed after 4 and 8 weeks after the given alcoholism to observe the results of the femoral head pathological changes : eight weeks after Guanjiu , the C group pathological changes are mainly concentrated in the rabbit femoral head subchondral area , intramedullary reduced hematopoietic tissue , fat substances increased proliferation and hypertrophy of fat cells , trabecular bone thinning , sparse , fracture , trabecular bone area fraction decreases . 4 weeks of empty lacunae increased , compared with the other three groups difference was statistically significant ( P <0.05 ) ; 8 weeks more obvious, and the difference was statistically significant ( P <0.01 ) compared with the other three groups . Conclusion: horse serum sensitization under the conditions given alcohol can cause within a short rabbit alcoholic osteonecrosis of the femoral head .

Related Dissertations

  1. Haihong Fruit Vinegar Processing Technology,TS264.22
  2. Study on Using Sepiolite As Supported Catalysts in Selective Hydrogenation of Cinnamaldehyde to Cinnamyl Alcohol,O643.32
  3. Modification for PVA-Based Composite Packaging Material with Nano-SiO2 and Its Influence on Fresh Preservation Effect of Salted Duck Eggs,TS253.46
  4. Non-contact Theoretical Analysis of the Measurement Technology for Detecting the Alcohol Content in Blood Using Raman Spectroscopy,U492.8
  5. Studies on the Extraction of Total Flavonoids from Momordica Charantia L. and the Production of Alcohol by By-product,TQ914.1
  6. The Expression of Rabbit Bordetella Bronchiseptica PRN Protein and the Study on Its Immunoprotection,S855.12
  7. Effect of Alcohol on Attention Using Attention Network Test,B841
  8. Study on Dehydration of tert-Butyl Alcohol Catalyzed by Functionalized Ionic Liquid,O643.32
  9. Experimental Study of Neural Stem Cells around the Lateral Ventricular Zone of the Hydrocephalus Rats,R742.7
  10. Direct Oxidation of Primary Alcohols to Methyl Esters Catalyzed by Nano-Au/SBA-16 Catalyst,TQ225.241
  11. The Expression Mechanism of Calmodulin in Rat with Brain Contusion,R651.1
  12. The Design of Chial β-Amino Alcohols and their Application to the Asymmetric Henry Reaction and the Asymmetric Reduction of Prochiral Ketones,O643.32
  13. Design and Synthesis of Novel Planar Chiral N-Containing Nucleophilic Catalysts and Their Applciations in Asymmertric Reaction,O643.36
  14. Generation and Trapping of an Active 2-Methylene 1,3-Dicarbonyl Intermediate,O621.3
  15. Research on Daily Load-forecasting for Power Grid Based on ANN,TM715
  16. Cytokines in C57BL/6 Mice Model of Hepatitis B Virus Infection,R512.62
  17. Transplantation of Umbilical Cord Mesenchymal Stem Cells into Cisterna Magna for Cerebral Hypoxic-ischemic Rat Model,R722.1
  18. Effects of Rem Sleep Deprivation on CRF and CRF Receptors mRNA in Depressive Rats’ Medulla Oblongata、hippocampus and Hypothalamus Treated with Chronic Stress,R749.4
  19. PVA sulfur- modified materials preparation, characterization and Cu (Ⅱ) and Ag (Ⅰ) Adsorption,O647.32
  20. Hard casting gas and environmentally friendly water-soluble polymer binder hardening mechanism of,TG221.1
  21. Cerium salt catalyzed 1,3 - dicarbonyl compounds and propargyl -Pot Synthesis of Substituted Furans research,O626.11

CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Bone diseases > Lower limb
© 2012 www.DissertationTopic.Net  Mobile