Dissertation > Excellent graduate degree dissertation topics show

Jiawei Dangguibuxue Tang Has an Impact on the Expression of Renal Tissue in Rats of Hyperlipidemia CTGF Protein and mRNA

Author: YeZhongWei
Tutor: ZhengXiaoWei
School: Zhejiang University of Traditional Chinese Medicine
Course: Chinese medicine
Keywords: Hyperlipidemia / TCM therapy Kidney disease / TCM therapy DBD / pharmacology
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 48
Quote: 0
Read: Download Dissertation

Abstract


Purpose : flavored Dangguibuxuetang , hyperlipidemia renal tissue connective tissue growth factor (CTGF) protein and mRNA expression of point of view , to explore its mechanism of action of anti - kidney damage . Method : flavored Dangguibuxuetang , high fat diet -induced kidney damage model for intervention , rats were randomly divided into normal group, model group , simvastatin group , the modified Danggui blood soup is low , medium and high dose groups each treatment group for intervention after 12 weeks of administration , immunohistochemistry technology semi-quantitative detection of CTGF protein expression levels of fluorescence quantitative reverse transcription polymerase chain reaction ( RT - PCR ) method detection CTGFmRNA the expression levels from each group other CTGF protein and mRNA expression levels of hyperlipidemia induced the kidney damage and flavored Dangguibuxuetang , its mechanism of action . Results: Immunohistochemistry results showed that the model of renal tissue CTGF protein expression was significantly higher than the normal group ( P lt ; 0.01 ) , each treatment group rat CTGF protein expression in varying degrees to reduce , the soup flavored Dangguibuxue high dose The most obvious group , followed by the positive control group , traditional Chinese medicine dose group and low dose group, fluorescent quantitative reverse transcription polymerase chain reaction ( RT - PCR ) test results show renal tissue of the model group was significantly higher than the normal group in CTGFmRNA have different degrees of reduction ( P lt ; 0.01 ) , the expression of each the treated rats CTGFmRNA the most obvious , of flavored Dangguibuxue soup high dose group , followed by the positive control group , dose group of traditional Chinese medicine , Chinese medicine low dose group . Conclusion: the flavored Dangguibuxuetang prevention and treatment of hyperlipidemia induced nephropathy mechanism may be lowered CTGF protein and mRNA expression .

Related Dissertations

  1. Mechanism of Huatan Huoxue Fang on Fat in Blood of Rats Hyperlipidemia Models,R285
  2. The experimental study of phlegm and blood side of the lipid-lowering effect and mechanism of hyperlipidemic rats,R259.8
  3. Clinical Research of Ziningjiangzhi Powder for Treated Hyperlipidemia,R259
  4. Flavored Gualou , Xiebai soup studies on the regulation of blood lipid and blood rheology of rats,R285.5
  5. Jiangsu Province Hospital of Nephrology, the use of Chinese medicine to treat kidney disease experience antagonists Jing,R277.5
  6. Dutch Film Treat Diabetes Liuhong Clinical Observation on Hyperlipemia,R259
  7. The Effects of Pu-erh Tea on Prevetion and Treatment of Tumor,R285.5
  8. Study of Oridonin on SGC-7901 Cell Proliferation by Inhibitting Cell Cycle Proteins,R285
  9. Study in Situ on Rat Intestinal Absorption Mechanism of Bazhen Decoction,R285
  10. Research of Glycosaminoglycan from Perna Virids Effect on Blood Lipid,R285.5
  11. Chemical Structures and Mechanism Research of Anti-aging Leading Compounds from Natural Products,R285.5
  12. Borneol,synthetic borneol and menthol on the P-glycoprotein and its mechanism,R285
  13. Study of Sepia Ink-Astragalus Preparation for Relieving Damage Caused by Chemotherapy,R285.5
  14. Inhibition of RAW264.7 Macrophage Inflammatory Cytokines Release by Guggulsterone,R285
  15. Study on the Pharmacokinetics of Xiaoaiping and Chlorogenic Acid in Rats and the Quality Standard of Xiaoaiping Preparations,R285
  16. Study of Triptolide Induced Hepato-toxicology by MS-based Metabonomics Approaches,R285
  17. The Antioxidative Efficient Component Recognition for Curcuma Longa L. Based on the Quality Control Pattern of Constituent Knock-out/Knock-in,R285
  18. The Study on Anti Tumor and Anti-oxidation Activities in Vitro of Extracts from Oxalis Corniculata L,R285
  19. Studies on the Molecular Mechanism of Anti-HBV Effect of Green Tea Extract Epigallocatechin Gallate,R285
  20. The Effect of Tanshinone ⅡA and Niacin on the Cardiovascular Function of Infant Obese Rat,R285.5
  21. Live alone the study of parasitic soup rabbit lumbar disc herniation model in vivo tumor necrosis factor in rats,R285.5

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile