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The Study of Treatmental Effect of Two Antibiotic to Neonatal Infectious Pneumonia and Their Effect to Neonatal Intestinal Microflora

Author: HuangMingHua
Tutor: LiShuoZuo
School: Central South University
Course: Epidemiology and Biostatistics,
Keywords: Newborn Antibiotic Time - effect analysis Intestinal flora Microecology ROC curve
CLC: R722.135
Type: Master's thesis
Year: 2003
Downloads: 149
Quote: 0
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Abstract


Neonatal infectious pneumonia observed in this study the efficacy of antibiotics commonly used antibiotics on the gut microflora . Neonatal infection in patients with pneumonia as the object of study, the use of antibiotics , grouped all the normal time of observation project terminated as pneumonia course of time , comparing the cure rate of the observation group and time - effect analysis . The quantitative analysis of the use of antibiotics for 3 days , 7 days intestinal flora in the six most representative bacteria content in order to understand the impact of the situation and the law of antibiotics on intestinal flora . The results show that : (1) the cure rate and the time of the penicillin group cephalosporin group , combination group - effect analysis showed no significant difference ; (2) the use of antibiotics for neonatal intestinal flora influential , its influence with the antibiotic time increases ; ( 3 ) three observer group on the gut microflora to the joint use of penicillin and cephalosporin group is the most obvious cephalosporin group , followed by penicillin group minimum ; ( 4) the use of antibiotics bacteria in the intestinal flora Bifidobacterium is the most obvious ; (5) (B / E value ) to determine the ratio of Bifidobacterium and Enterobacteriaceae ( screening method ) intestinal flora status when , B / E , the value of 1.01 with the best screening effect . This study suggests : neonatal infections still need to start from the basic medicines , free to use efficient broad-spectrum antibiotics , and casual joint use of antibiotic treatment is not desirable ; impact of antibiotics on the gut microflora should be included in the side effects of antibiotics considered .

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CLC: > Medicine, health > Pediatrics > Newborns, premature children disease > Neonatal disease > Infection of the newborn > Neonatal pneumonia
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