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Research on Pharmaceutical and Preliminary Pharmacodynamics of Sanjiezhitong Cataplasm

Author: WangLiMei
Tutor: ZhouChangZheng
School: Shandong University of Traditional Chinese Medicine
Course: Pharmacy
Keywords: Sanjie pain cataplasm Breast hyperplasia Orthogonal test Preparation process Quality standards
CLC: R283
Type: Master's thesis
Year: 2010
Downloads: 96
Quote: 0
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Abstract


Sanjie pain cataplasm prepared from extracted by re-building, diffusa, Prunella, ChuanWu Araceae, borneol Liuwei traditional Chinese medicine, with Endometriosis, swelling analgesic effect. For the pathogenesis of breast hyperplasia, prescription weight floor Hedyotis diffusa qingrejiedu, swelling and pain stasis, and into hepatogastric two classics directly to breast disease by; Prunella can pass through into Sanjie pain; borneol Xinsan take channeling, swelling and pain. Various drugs, topical disease location, enables the drugs directly to patients, detoxification Sanjie active Quyu Tongluo analgesic power. Firstly heavy polyphyllin, ursolic acid, hypaconitine HPLC content determination method by orthogonal experiment, to the active ingredient Paridis anti-breast hyperplasia saponins, ursolic acid and analgesic efficacy hypaconitine extraction rate evaluation, focusing on the effects of ethanol concentration and adding volume, three factors of reflux time. Ultimately determine the alcohol extraction process to join the prescription medicinal eight times the amount of 70% ethanol was heated to reflux extracted twice, each time 1.5h. Using uniform design method to optimize the cataplasm the molding process, with a uniform design version 2.0 software to filter out the M12 (12,5) table arrangements experiments, the initial viscosity of the of cataplasm blank matrix, Peel, the three factors of the gel strength test Chaba the matrix blank moldability of the cloth agent, obtained by the test matrix formulation optimized for: kaolinite: Povidone: glycerol: water NP-600: the best ratio of the NP-700: 0.1:0.2:1:3.5:0.2 : 0.3. Validation studies have shown that the uniform design method is accurate and reliable. Sanjie analgesic cataplasm quality standards. Including heavy floor, herbs, Prunella and Hedyotis diffusa The TLC; the main pharmacodynamic ingredients Paridis saponin content measurement method established; the cataplasm basic routine examination containing paste quantity, adhesion, and formability. The examination showed that the amount of gypsum Sanjie analgesic poultice, adhesion, and shaped to meet the requirements of the Chinese Pharmacopoeia; heavy floor saponins Sanjie pain cataplasm cataplasm every piece of not less than 2.0 mg. The hypaconitine the active ingredient in the prescription and ursolic transdermal absorption law to do the study, results showed that: ursolic acid itself is difficult to need some transdermal through the skin to promote effective agent role can through the skin, and a low permeability coefficient. Hypaconitine through the skin's ability to join after transdermal penetration enhancers faster.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Chinese medicine processing,preparation
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