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Studies on the Chemical Constituents of Two Nontoxic Medicinal Plants from Rhododendron

Author: SongHeJiao
Tutor: LiRongTao
School: Kunming University of Science and Technology
Course: Medicinal Chemistry
Keywords: Genus Rhododendron Brown back azaleas R. delavayi Chemical composition Flavonoids
CLC: R284
Type: Master's thesis
Year: 2009
Downloads: 83
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Abstract


Ericaceae (Ericeae), the thesis of both the genus Rhododendron (Rhododendron) medicinal plants brown back azalea (Rhododendron alutaceum Balf (f)) and Lantana azalea (Rhododendron delavayi Franch.) The chemical composition of the system. Using various separation and purification means, such as thin layer chromatography, silica gel column chromatography and ODS reverse phase column chromatography, MCI-gelCPH-20P column, Sephadex LH-20 gel column, MPLC (medium pressure column chromatography) and HPLC (highly efficient liquid chromatography), 35 compounds were isolated from the two medicinal plants. The integrated use of nuclear magnetic resonance (1H-NMR, 13C-NMR and 2D-NMR) and mass spectrometry (MS) and other modern spectroscopic techniques identified the structure of the compound, including three new compounds, respectively, for a new double half-timbered visfatin, a new phenolic glycosides and a new wooden quinoa Lo alkanes diterpenes. The type of structure known compounds involves a half times lignans, lignan glycosides, diterpenes, triterpenes, flavonoids and glycosides, steroid. Brown back azaleas evergreen tree, located in the local region of Yunnan, Sichuan. Rhododendron leaves collected from Dali Cangshan brown back this thesis, a study of the chemical composition, from 75% acetone - water extract isolated 27 compounds, including three new compounds named alutaceuol (1), of alutaceuketoside (2 ), alutaceusin Ⅰ (3), other compounds Acernikol (4), ficusequilignan A (5), Ehletianol C (6), Japan Rhododendron prime - Ⅲ (7), wood lambsquarters Lo toxin - Ⅲ (8), sheep downtown flower toxin - Ⅱ (9) ,7,8-Dihydrobenzofuran-7-(4-hydroxy-3-methoxyphenyl)-3-aL-rhamnopyranosyloxymethyl-3'-methoxy-1'-prop-anol (10), hyperin (11), quercetin-3-O-α-D-Arab pyrazol feeding the glycosidic (12), catechins (13), quercetin (14), the bayberry ketone (15), Niga-ichigoside F2 (16), Niga- ichigoside F1 (17), 2a, 3β, 23 - trihydroxy usu -12 - en-28 - acid-28-O-β-D-pyran-glucoside (18), 2α, 3β, 23 - trihydroxy Homogeneous Dun -12 - en-28 - The acid-28-O-β-D-pyran-glucoside (19), 3β, 19α, 23 - trihydroxy usu -12 - en-28 - acid-28-O-beta -D-glucopyranose glycosides (20), 2α, 3β, 19α-trihydroxy usu -12 - en-28 - The acid-28-O-β-D-pyran-glucoside (21), ursolic acid (22 ), β-carrot glycosides (23), the β-sitosterol or alcohol (24), Epirhododendrin (25), (2S) -4 - (3,4-dihydroxyphenyl)-2-butanol (26), (2S) -4 - (4-hydroxyphenyl)-2-butanol (27). The brown back azaleas chemical composition reported for the first time. Lantana the azalea distribution in Guangxi, Guizhou, Yunnan and other places. The experiment collected from of Yunnan Province Jingdong Wuliangshan an altitude of 2250 m at the Lantana azalea stems conducted study of the chemical composition. Eight compounds were isolated from 75% acetone - water extract, are known compounds were identified as: 3 ', 4', 7 - trihydroxy -3,5 - dimethoxy flavone (1) 3 ', 4', 5,7 - tetrahydroxybenzophenone -3 - methoxy flavanone (2), quercetin-3-O-beta-D-Arab pyranoside (3), catechin (4), Table catechin (5), epicatechin-(2β → O → 7,4 of β → 8)-ent-epicatechin-(6), (2S) -4 - (3,4 - dihydroxyphenyl yl) -2 - butanol (7), (3,4 - dihydroxyphenyl yl) -2 - ethanol (8). Compound 2,3,6,7,8 for the first time from this plant.

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