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The Chinese Herbal Compound Effect on Spleen-deficiency AR Rats Nasal Mucosa IL-2, β1-Defensin mRNA and Serum IgE Expression

Author: BoXianCe
Tutor: XiongDaJing
School: Chengdu University of Traditional Chinese Medicine
Course: TCM features science
Keywords: Spleen deficiency Allergic Rhinitis β1-Defensin IL-2 IgE
CLC: R285.5
Type: Master's thesis
Year: 2010
Downloads: 31
Quote: 0
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Abstract


Objective: allergic rhinitis are in medical \The instructors Bear Dajing good at the Spleen, clinical quite effective, so the animal experiments, from pathological, biochemistry and molecular biology, the herbal compound Spleen-type AR rats indicators. Methods: SD rats were randomly divided into 7 groups. ① the blank group 2 Spleen Qi Deficiency spleen deficiency AR group ③ ④ spleen qi deficiency AR AR TCM group WM group ⑤ AR group ⑥ the AR TCM group ⑦ AR western medicine group. Established using improper diet and fatigue spleen-deficiency animal model, reported by An Yunfang method to establish a model of allergic rhinitis. Drug Intervention: In addition to the blank group, spleen deficiency AR group, AR group, the rest of the group a day be the appropriate drug intervention be 1 hour after administration of 5% ovalbumin solution the local half the amount of excitation. From the first day of modeling to observe animal behavior, state, signs, feeding, drinking water, toilet traits such as within 30 minutes after the excitation focus on observation of nasal symptoms, nasal itching, sneezing, nasal secretions, and nasal symptoms score after the last shot. Seven days after treatment, the rats were detected nasal septum mucosa HE staining, serum IgE, IL-2 mRNA, β1-Defensin mRNA in changes. Results: Spleen AR group and the integration of the AR group were more than 5, spleen AR group, integral with the integration of the AR group compared differences. Seven days after treatment the nasal scores of the treatment group compared with the model group difference (p lt; 0.05) compared with the control group no difference (p gt; 0.05). And each treatment group and the western medicine treatment group compared to the nasal score difference (p gt; 0.05). Serum IgE: Spleen AR group and AR group compared with the control group showed significant differences (p lt; 0.01). Spleen AR group compared with the AR group statistically significant difference (p lt; 0.05); each treatment group compared with the AR group significant difference (p lt; 0.01), no difference compared with the control group (P gt; 0.05 ). IL-2 mRNA expression: Spleen AR group and AR group compared with the control group showed significant differences (p lt; 0.01). Spleen AR group compared with the AR group statistically significant difference (p lt; 0.05); each treatment group compared with the AR group significant difference (p lt; 0.01), no difference compared with the control group (P gt; 0.05 ). The β1-Defensin mRNA expression: the spleen AR group and AR group compared with the control group a significant difference (p lt; 0.01). Spleen AR group compared with the AR group statistically significant difference (p lt; 0.05); each treatment group compared with the AR group significant difference (p lt; 0.01), no difference compared with the control group (P gt; 0.05 ). Conclusion: Spleen can aggravate the AR rats nasal symptoms. The herbal compound can significantly improve the nasal mucosa pathological response; through a multi-level, multi-angle adjustment related cytokine mRNA expression, and a good role in the prevention and treatment of AR.

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