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Study on the Online Expert System of Traditional Chinese Medicine HPCE Fingerprints

Author: LiuJinDan
Tutor: SunGuoXiang
School: Shenyang Pharmaceutical University
Course: Pharmaceutical Analysis
Keywords: Expert system HPCE Fingerprinting ZDP Melon pedicle Thirty-seven Super - information feature Dual qualitative and dual quantitative similarity Unified fingerprinting
CLC: R284
Type: Master's thesis
Year: 2008
Downloads: 48
Quote: 1
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The papers summarize and generalize the existing literature and experimental basis, to build a system of traditional Chinese medicine by high performance capillary electrophoresis fingerprints (HPCE) fingerprint experts. According to the expert system has been established, the the ZDP, melon pedicle and notoginseng HPCE fingerprints, and expert system for super-information characteristics of chromatographic fingerprints Digitized Evaluation System 3.0 Software shamisen Chinese medicine HPCE fingerprinting super features digitized evaluation dual qualitative the dual quantitative evaluation and harmonization evaluation. Preliminary validation of the usefulness of the expert system, and at the same time for the the ZDP, melon the pedicle and thirty-seven quality control to provide a new method. Build Chinese medicine HPCE fingerprint expert system, according to the structure of the expert system, the details of the overall framework of the two main parts of the the Chinese medicine HPCE fingerprint expert system knowledge base and the inference engine design and reasoning processes, which include sample pretreatment method Recommended operating conditions of capillary electrophoresis, capillary electrophoresis, optimization of the operating conditions of three aspects. 2, after the test is carried out according to the method recommended by the expert system, respectively, uniform design method and triangle optimization method to optimize the the ZDP extraction methods and background electrolyte, chromatographic fingerprint index (F) for the evaluation of indicators, while the detection wavelength separation voltage auxiliary conditions to optimize the eventual establishment of the ZDP HPCE fingerprints. Evaluation software with expert system of qualitative and quantitative information on the the ZDP fingerprint implied many sides a full range of data mining, intuitive and fully demonstrated the characteristics of the the ZDP digital fingerprint to 46 parameters . 3, in order to establish the expert system for guidance, based on the background electrolyte recommended by the general method of the expert system and optimization steps into the experiment and optimization, while optimizing the extraction conditions, the detection wavelength and separation voltage, and the eventual establishment of a melon pedicle HPCE fingerprint, fingerprint evaluation software is a comprehensive study of the qualitative and quantitative similarity of melon pedicle fingerprint variation; simultaneously with dual the qualitative similarity S_F and S_F 'dual quantitative similarity of C and P evaluated melon pedicle Fingerprint Chromatogram for melon pedicle The medicinal quality control provides a new reference method. Expert system recommended the Araliaceae the background electrolyte conditions on the basis of the test, and system optimization steps recommended optimized background electrolyte composition, extraction conditions and separation voltage, and the eventual establishment of notoginseng HPCE fingerprint. Notoginseng HPCE fingerprints unification, and the different unification of parameters reveals the relative characteristics of the fingerprint. HPCE fingerprints created for the notoginseng quality control provides a new reference method, unified fingerprinting all chromatographic fingerprint made in the same coordinate system to facilitate comparison fingerprinting and conducive Chemometrics fuzzy identification method.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical
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