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Compound Chinese medicine of Yu Yue sparse experimental study of the impact of post-stroke depression in rats

Author: WangZuoYu
Tutor: LiuFuYou
School: Chengdu University of Traditional Chinese Medicine
Course: Traditional Chinese Medicine God within
Keywords: Post-stroke depression Rats Animal models Behavior Monoamine neurotransmitters Yu Yue sparse
CLC: R277.7
Type: Master's thesis
Year: 2004
Downloads: 123
Quote: 0
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Objective: Preparation of post-stroke depression (PSD) rat model . Observation of compound Chinese medicine Yu music thinning of the PSD rats depressive behavior and brain monoamine neurotransmitters , to explore its mechanism . Method : cause rat right brain artery occlusion (MCAO) rat model of focal cerebral ischemia , based on comprehensive solitary raising short-term mild unpredictable stress treatment the composite preparation PSD rat model . Use Longa 5 -point rating the stroke rat nerve function ; experiments using sucrose consumption , open box experiment assessed the PSD rats depressive behavior change ; using fluorescence spectrophotometric determination of bilateral frontoparietal cortex and brainstem monoamine neurotransmitters : nor- epinephrine ( NE ) , 5 - hydroxyl tryptamine (5-HT), dopamine (DA) content . Yu Yue thinning of the PSD rats depressive behavior and brain monoamine neurotransmitters . Results : PSD rat model appears obvious neurological deficit , weight gain slowed down compared to the other rats , a significant reduction in sucrose consumption activities low openfield , bilateral frontoparietal cortex and brainstem monoamine neurotransmitters were significantly lower . Of Yu Yue sparse can significantly improve the PSD rats sugar consumption , improve abnormal activities openfield , increasing the PSD the rat brain NE , 5 - HT content . Conclusion : MCAO rat model based on composite solitary raising and short-term mild unpredictable stress treatment can be prepared better PSD rat model . Of Yu Yue sparse can significantly improve the PSD rats depressive behavior ; may increase the PSD rat brain monoamine neurotransmitters . Its antidepressant mechanism of action may be related with the increase in the content of monoamine neurotransmitters and improve brain function .

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