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Reference Value and Predicted Equations of Lung Function of Healthy Children in Soochow
Author: LuYanHong
Tutor: HaoChuangLi
School: Suzhou University
Course: Pediatrics
Keywords: Pulmonary ventilation maximal voluntary ventilation Peak expiratory flow Child Reference value
CLC: R725.6
Type: Master's thesis
Year: 2011
Downloads: 30
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Abstract
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Objective:To undertake the reference value and establish the prediction equations of normal lung function for children in Soochow.Methods:509 healthy children (251boys, 258girls) , aged from 5 to 14 years old in Soochow, were involved in this research in 2010.①Twenty-three tests parameters [e.g. forced vital capacity (FVC), forced expiratory volume at one second (FEV1), maximal voluntary ventilation (MVV), peak expiratory flow (PEF)] were measured by using Jaeger spirometer. Stepwise multiple regressions, and non-linear regressions were carried out with the statistical software SPSS 16.0 for Windows to identify the best predictors of the lung function parameters using standing height, weight, age and gender as potential determinants. Analyze the correlation between PEF and FEV1, establish the regression equation for MVV and research the correlation between MVV and FEV1.②Use Peak Flow meter to measure PEF and establish the regression equation for PEF, study the difference of PEF value measured by Peak Flow meter and spirometer separately.Results:1. FVC shows significant difference in different age groups, while in the same age group, FVC in the boys is higher than girls(P<0.05).2. FEV1 increases significantly with age, and in the same age group, gender is an independent variable: Boys’FEV1 is higher than girls’(P<0.05).3. Positive correlation is found between height, weight, age and spirometric parameters. Above all, height is the best determinant among the majority of the spirometric parameters. Multiple regression equation is established for every spirometric parameter. There is an index number relationship between height and FEV1, and rectilinear correlation is found between PEF and FEV1. So it is the same with MVV and FEV1.4. Children’s average expiratory duration is 2.68s, volume of back extrapolation is 0.12L, the rate of back extrapolative volume to forced vital capacity is 4.97%.5. The PEF measured by Peak Flow meter has a positive rectilinear correlation with height, and has a positive rectilinear correlation with PEF measured by spirometer.Conclusion:1. FVC and FEV1 , both show significant difference among different age groups. And in the same age group, the parameters of male is larger than those of female on the whole. Among the determinants of spirometry, height is more significant than weight and age. Among the parameters measured by spirometry, PEF has a positive rectilinear correlation with FEV1 and there was a positive rectilinear relationship between MVV and FEV1. Children’s lung reserve function can be evaluated through prediction value of MVV, which can be calculated by regression equation for FEV1 and MVV.2. Children average expiratory duration is shorter than that in adults (6s). In the quality control, the children expiratory duration should be standardized by appearance of a respiration platform instead of being forced to achieve 6s. Children’s quality control is different from that in adults’.3. The PEF measured by Peak Flow meter has a positive rectilinear correlation with height, and predicted value of PEF can be calculated by regression equation for children’s height. The PEF measured by Peak Flow meter has a positive rectilinear correlation with PEF measured by spirometer therefore, the later could be replaced by PEF measured with Peak Flow meter.
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