Dissertation > Excellent graduate degree dissertation topics show

The Effect of Selective Digestive Decontamination in Sever Acute Pancreatitis in Rats

Author: NieLei
Tutor: ZhangXunChen
School: Wuhan University
Course: Surgery
Keywords: sever acute pancreatitis selective digestive decontamination bacterial translocation infection inflatmmatory response
CLC: R576
Type: Master's thesis
Year: 2004
Downloads: 59
Quote: 0
Read: Download Dissertation


Objective: To explore the effect of selective digestive decontamination (SDD) to decrease bacterial translocation and relieve inflatmmatory response in sever acute pancreatitis (SAP) in rats.Methods: The Sprague-Dawley rats were divided randomly into norm group, sham-operated group, SAP group, SDD group. SAP was induced by intraductal injection of 4% sodium taurocholate. SDD group underwent bacterial decontamination through the administration of Gentamycin, Polymyxin and Nystatin during the 3 days prior to SAP induction. 24 hours after SAP induction, laparotomy was performed and samples for the bacterial culture of pancreas, lung, liver, spleen and kidney was obtained. Intestinal bacteria was counted. A point scoring system of histologicalal features was used to evaluate the severity of pancreatitis. The levels of blood endotoxin in portal vein and plasma TNF alpha in venae cavae were measured. Pancreatic myeloperoxidase (MPO) were detected at the same time.Results : In the SAP and SDD group, there was significant pancreatic and extrapancreatic infection 24 hours after induction of pancreatitis, counting of intestinal bacteria, plasma concentrations of endotoxin and TNF alpha were significantly higher than in norm group and sham-operated group controls. Compared with SAP group, all of above-mentioned indexes were decreased in SDD group.Conclusions The incidence of bacterial translocation and the severity of SAP can decreased by SDD prior to SAP induction.

Related Dissertations

  1. Professor Zhang Shuwen academic thinking,and 59 cases of Chinese and Western medicine combined with clinical research for diagnosis and treatment of acute pancreatitis,R249.2
  2. Study on Sorghum Sudanense Leaf Spot Caused by Bipolaris Sorghicola,S435.4
  3. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  4. Research Oven Based on Keeping Cakes’ Original Cuisine,TS210.3
  5. Urban and rural women high-risk human papillomavirus infection status and epidemiological studies of risk factors,R737.33
  6. Study on Parasite-host Relationship and Grooming Behaviors of the Two Bamboo Bat Species,Q958
  7. Analyses on Plasmodium Infection Status of Peacekeeping Force and Local Residents in Congo (DRC) and the Difference of the Malaria Report Method between the Level Ⅱ Hospital and Local Hospital,R531.3
  8. Impact of Ischemic Preconditioning on Bacterial Translocation and Rejection in Rats Intestinal Transplantation,R656.7
  9. Influence of Bifidobacterium on Gut Barrier Function and Th1/Th2 Cytokine in Food Allergic Mice,R593
  10. SARS-Cov Spike Protein-pretreated Bronchial Epithelial Cells Step Up Inflammation in the Lung After Exposure to Lipopolysaccharide,R56
  11. Treatment of Device-Related Infection in Rabitts by High Requency Electric,R687.3
  12. Application of Mathematical Models to Estimate the Schistosoma Japonicum Infection Status at the Population Level,R532.21
  13. Analysis on Efficacy and Cost-effectiveness of Four Treatment Methods for Acute Exacerbation of COPD Bacterial Infections,R563.9
  14. The Research of the Relationship between the Hepatitis B Virus Markers and HBV DNA in HBsAg Negative Serum,R512.62
  15. Relationship Between H. Pylori Infection and Improvement of Different Subtypes of Functional Dyspepsia,R57
  16. Effect of Dendritic Cells from Intestinal Lamina Propria on Activation of Cd4~+ T Cells in Post-infectious Visceral Hypersensitivity Mice,R574
  17. The Relationship between IFN-γ and XCL1 in Serum of Hepatitis B Patients,R512.62
  18. Genetic Variation in LMP/TAP Gene and the Outcomes of Hepatitis B or C Virus Infection in the Chinese Population,R512.6
  19. HIV-1 latent Jurkat T cell model and epidemic strains of HIV -1 B / C recombinant subtype infection of human umbilical cord blood hematopoietic progenitor cells,R512.91
  20. Clinical Research of Causation and Treatment about Infection after Internal Fixation of Bone Fracture,R687.3
  21. Clinical Analysis of 15 Cases with Pulmonary Infection after Renal Transplantation,R699.2

CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Pancreatic diseases
© 2012 www.DissertationTopic.Net  Mobile