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Transition metal Schiff base ligand complexes formed more and more people's attention. Structural diversity of the complexes, the special nature of extensive research in the field of chemical, biological, and materials science. Of integrated a lot of literature, the design and synthesis of the 14 kinds of transition metal complexes (seven kinds of Schiff base complexes), and the crystal structure of these complexes, the biological activity was studied. Achieved the following results: 1. Synthesis of salicylaldehyde with glycine (HL1), salicylaldehyde with N-(2 - aminoethyl) morpholine (HL2) - chlorosalicylaldehyde aldolase fluorophenyl methylamine ( HL3), salicylaldehyde 4 - (2 - aminoethyl) phenol (HL4) and salicylaldehyde 4 - (2 - aminoethyl) benzenesulfonamide (HL5) five kinds of Schiff base ligands, so with The role of the transition metal Cu2, Ni2, Mn2, forming a Schiff base complex, wherein the cultivation of the seven kinds of a single crystal of the complexes, and their structures were determined by X-ray diffraction method, Cu (L1) (py) (H2O) [Cu (L2) (Py) (H2O)] (ClO-4) · H2O, Cu (L4) 2.2 H2O, Ni (L4) 2.2 H2O, Ni (L5) 2 as mononuclear complexes; Cul1 2.2 / 3 (CH3OH), [Mn2 (L5) 2 (N3) 2] (OCH3) 2 binuclear complexes. 2 synthetic ligand 2,5,8 - three nitrogen -1,9 - two (2 - fluorophenyl) nonane (HL6), Cu2 and Co2 role in the formation of transition metal complexes, and cultured for 2 The kinds of the single crystal of the complexes, their structure was determined by X-ray diffraction method, [Cu (L6), (Cl-)] (ClO-4), and Co (L6) (N3) 3 are both mononuclear complexes . 3 to 6 kinds ligand (HL1 ~ 6), and the nine kinds of complexes as enzyme inhibitors, and the test they inhibit urease (Urease) and xanthine oxidase (Xanthine Oxidase, abbreviated as XO, the same below) of the biological activity. The results show that complexes of Ni, Mn, Co three elements: these organic ligands are not inhibit urease (Urease) and xanthine oxidase (XO), the biological activity; Cu element complexes have suppressed the activity of the two enzymes; inhibiting the activity of urease (Urease), but did not inhibit the activity of xanthine oxidase (XO). The preliminary study the relationship of these compounds inhibit enzyme activity and its molecular structure, and in-depth analysis of the structure-activity relationship substances inhibit urease activity \In addition, 3 - pyridine carboxylic acid, 2 - amino benzoic acid, 3,5 - dinitrosalicylic acid, terephthalic acid, 4,4 '- biphenyldicarboxylic acid and 1,6 - hexamethylene diamine, 2 - amino pyridine, 4 - aminopyridine, 2 - aminopyrimidine as raw materials also synthesized Ag (I) transition metal complexes, and train its monocrystalline. Using the same method and means of their crystal structure and inhibit the biological activity of the enzyme, and analysis study of the five kinds of Ag (I) of complex structure of the compounds with the inhibition of urea enzyme (Urease) activity relationship, further expanding the inhibit urea enzyme the field of study of the active substance.
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