Dissertation > Excellent graduate degree dissertation topics show

Relationship between Siderophage and Wound Age

Author: ZhengAiPing
Tutor: FengQiong
School: Nanchang University
Course: Pathology and Pathophysiology
Keywords: Forensic pathology Injury time estimation Hemosiderin macrophages Prussian blue staining
CLC: D919
Type: Master's thesis
Year: 2007
Downloads: 126
Quote: 1
Read: Download Dissertation

Abstract


The purpose of experimental studies in mouse skin wound healing process of the organization containing the relationship between the variation of the the Jagged the flavin macrophages number of changes and injury time to provide theoretical and experimental evidence for histopathological new method of inference of injury time. Copy mice blunt creator (laceration record) and sharp record (the incised wounds) animal model, application of Prussian blue staining hemosiderin macrophages changes in damaged tissue in the different survival time points. 145 Km mouse and blunt founding group were randomly divided into, and sharp invasive group (experimental group), 70 in each group, and then randomly divided into two groups within the 14 different injury time group (6h, 12h, 1d, 2d , 3d, 4d, 5d, 6d, 7d, 8d, 9d, 11d, 13d, 15d), n = 5; another five injured mice as normal controls. Different injury time, the animals were sacrificed in turn, taken for histopathological observation. Results (1) mice blunt invasive and sharp record different injury time in the gross and histopathological observation were significantly changed. Normal skin tissue in the control group showed no hemosiderin macrophages; experimental group mice blunt creator and sharp invasive tissue repair skin damage zone each time point margin of tissue are visible in varying amounts hemosiderin macrophages, with the control group, there were significant differences (P <0.05). (2) after blunt invasive and sharp record tissue repair process, the margin of tissue damage zone containing closely related to changes in the number of macrophages with hemosiderin histopathological staging; hemosiderin macrophages number gradually increased in the inflammation of the increase of injury time after injury, respectively 5d 7d and peaked later decreased with a further extension of the time of the injury. (3) compared with the sharp invasive group, severe blunt invasive tissue injury, hemosiderin macrophages peak higher peak compared to the the sharps record group, the peak time is also longer. Conclusion: (1) in mice blunt invasive and sharp invasive skin creating more process in damaged tissue hemosiderin macrophages number of exudation and is closely related to histopathological staging, with injury time was typical biphasic changes in the relationship; (2) the damaged tissue containing hemosiderin macrophages and tissue injury type and extent of closely related; (3) of inference: the application of Prussian blue staining hemosiderin in the skin Chuang Chuang more yellow prime number of macrophages changes, may be the development of a new method of the time of an inference tissue damage.

Related Dissertations

  1. The Experimental Study in the Evaluation of Inflammatory Grading of Liver Fibrosis Using SPIO-enhanced 3.0-T MR Macrophage Imaging,R575.2
  2. Dynamic Changes of Calpain1 and Calpain2 after Traumatic Brain Injury in Rats,D919
  3. The Study on Changes of Expression of PSD-95 after Brain Contusion in Rats,D919
  4. Tracking Neural Stem Cells in Host Brain by Magnetic Resonance,R651.15
  5. Tidal volume ventilation induced rabbit VILI modeling and IL-1β, NF-κBp65 expression,D919.1
  6. Study on Relation between the Expression of S-100β& MBP and Traumatic Subarachnoid Haemorrhage in Brain of the Acute & Chronic Alcoholism Rats,D919.1
  7. Estimation of Early Postmortem Interval with β-actin mRNA Degradation in Rat’s Brain, Heart and Kidney,D919
  8. Estimation of Postmortem Interval Using microRNA and 18S rRNA Degradation in Rat Cardiac Muscle,D919
  9. An Experimental Study on the Expression of Neuropeptide Y and PGC-1α in a Rat Model of Stress Cardiomyopathy,R542.2
  10. Autopsy Reports of Cases and Review in Forensic Pathology,D919
  11. Associativity Study between Housekeeping Genes mRNA Degradation Regularity in Dead Rats and Advanced Stage Postmortem Intervals,Q953
  12. Postmortem Interval Estimation Based on Corneal Image Classification & Retrospective Study on Poisoning Death in Central China,D919
  13. Study of Detecting Spoilage Microorganism and Spoilage Product for PMI Estimation,D919
  14. Study on the Relationship of Narrowing of the Sinus Node Artery and Sudden Death, Apoptosis, the Matrix Change in Sinus Node,D919.1
  15. The Forensic Pathological Study on Sudden Coronary Death,D919.4
  16. Skin wound healing process of TLR2, TLR4 expression and Forensic Significance,D919
  17. A Study of the Relationship between the Postmortem Interval and the Degradation of Cardiac Troponin I and Skeletal Troponin I in Rats,D919
  18. The Expression of the Tryptase and Chymase in the Traumatic Patients, AMI and the Human Sudden Erethistic Death,D919
  19. A Study on the Time-dependent Expression of C-jun during the Incised Skin Wound Healing in Mice,D919
  20. A Study on the Time-dependent Expression of Phospho-CB1R during Repair of Contused Skeletal Muscle in Rats,D919

CLC: > Political, legal > Legal > UNIVERSITY > Forensic
© 2012 www.DissertationTopic.Net  Mobile