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The Effects and Safety of Rocal Pulse Therapy Combined with Low Calcium Dialysis in Patients with Secondary Hyperparathyroidism (SHPT) Undergoing Haemodialysis

Author: MengYan
Tutor: ChenJiangHua
School: Zhejiang University
Course: Internal Medicine
Keywords: chronic renal failure secondary hyperparathyroidism(SHPT) Rocal pulse therapy low calcium dialysis
CLC: R692.5
Type: Master's thesis
Year: 2008
Downloads: 86
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Abstract


Objective: To observe the curative effects and safety of Rocal pulse therapy combined with low calcium dialysis in patients with secondary hyperparathyroidism undergoing haemodialysis.Methods: 46 patients were divided into 3 groups according to the level of parathyroid hormone （iPTH）. Patients in Group A were with 300pg/dkiPTH≤600 pg/dl, receiving orally Rocal 0.5-1ug, two or three times one week; Patients in Group B were with 600pg/dl<iPTH≤1000pg/dl, receiving orally Rocal 1-2ug, two or three times one week; Patients in Group C were with iPTH >1000pg/dl, receiving orally Rocal 24ug, two or three times one week. The pills were taken in the evening after haemodialysis. The concentration of Ca2+ in dialysis fluid was 1.25mmol/l. The dosage of Rocal was adjusted based on the level of iPTH. The serum levels of iPTH, alkaline phosphatase （AKP）, calcium(Ca2+), phosphonoum(P3+) and albumin（Alb） were measured at baseline and after therapy.Results: There were no significant difference on serum levels of Ca2+, Alb,AKP between baseline and after treatment （P>0.05）. The serum levels of P3+,Ca×P, iPTH decreased significantly（P<0.05）. And the above levels of patientsin Group A or Group B decreased more early and fastly.Conclusion: Rocal pulse therapy combined with low calcium dialysis candecrease the level of iPTH in patients undergoing hemodialysis with secondaryhyperparathyroidism. There was few incidence of hypercalcemia.

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CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Kidney disease > Renal failure
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