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4,6 - dihydroxy- pyrimidine synthesis and kinetics

Author: CuiLong
Tutor: JiangDengGao
School: Zhengzhou University
Course: Chemical processes
Keywords: 4,6 - dihydroxy- pyrimidine Thermodynamics Synthesis Dynamics
CLC: TQ254.1
Type: Master's thesis
Year: 2011
Downloads: 96
Quote: 0
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Abstract


Pyrimidine compounds have anti-fungal effects for biological growth regulation is widely used in the preparation of pharmaceuticals and pesticides . 4,6 - dihydroxy- pyrimidine- pyrimidine compounds are important synthetic intermediates , this paper 4,6 - dihydroxy- pyrimidine problems in the production process , its synthesis technology for a more systematic study . The text of the 4,6 - dihydroxy- pyrimidine synthesis reaction thermodynamic data were calculated by the relevant chemical reaction equilibrium constant process conditions for the design and production of a thermodynamic basis . In this paper, malonate and formamide as the raw material of sodium in methanol catalyzed by single factor and orthogonal experimental design for 4,6 - dihydroxy- pyrimidine process was optimized to obtain the optimum conditions for the : the reaction temperature is 50 ℃, reaction time 3h, sodium concentration 30%, n ( malonate ): n ( formamide ): n ( sodium ) = 1:2.6:3 . In this condition , 4,6 - dihydroxy- pyrimidine yield can reach 82.09% , and the product was confirmed by IR analysis proved correct structure . Optimized synthesis process has short reaction time, with less raw material , mild reaction conditions is easy to operate and so on. Study isothermal method of the synthesis reaction system apparent kinetics , the experimental determination of the synthesis system in different time yield of the reaction product obtained within the experimental reaction yield can more accurately described as the reaction time and reaction temperature and feed ratio changing dynamics equation , kinetic model was established and has been the model parameters . The results showed that under the experimental conditions , reactions were subject to two irreversible kinetic model . Experiments also verify the reliability of the resulting kinetic model for its industrial production provides an experimental basis .

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CLC: > Industrial Technology > Chemical Industry > Basic Organic Chemistry Industry > The production of heterocyclic compounds > Containing six pairs or more different atoms of heterocyclic > (B ) pyridine ( pyrimidine ) family
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