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Prearation and Pharmacodynamics Studyes on Zhizichitang Oral Liquid

Author: WangXiuHai
Tutor: TianMing
School: Heilongjiang University of Traditional Chinese Medicine
Course: Chinese medicine
Keywords: Gardenia Black Bean Soup oral solution Preparation Process Quality standards Pharmacodynamic
CLC: R285
Type: Master's thesis
Year: 2011
Downloads: 107
Quote: 1
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Abstract


Gardenia Black Bean Soup from \syndromes, the party is not only the basis for the treatment of thermal disturbance Xiongge card party, is the basis of party treatment Yangming stagnant heat, modern clinic for the treatment of menopausal depression, insomnia, neurasthenia disease, as long as they meet the attending lesions card The machine can also be flavored use, treatment of esophagitis, acute gastritis, cholecystitis. Through a lot of literature, concluding, gardenia Miso Soup Clinically, there is still a wide range of applications, and has broad prospects for development and utilization. Gardenia Miso Soup been decoction form of clinical use, according to the technical requirements of Chinese Drug Research, the development of oral liquid formulations of proprietary Chinese medicines, based on retaining the characteristics and advantages of the original side, take, save and more convenient to carry. This paper studies the the gardenia the Miso Soup oral preparation process, develop quality control standards, initial stability test, and preliminary pharmacodynamic effects of oral liquid preparations of animal models of depression. Preparation Process of the material basis of drug action, multiple indicator measuring, comparing the modern technology and traditional crafts to develop a reasonable process route. Genistein, geniposide content as an indicator, univariate and multivariate orthogonal experiment method to determine the best extraction process: herbs plus 6 times the amount of water, soak 1.5h heated to reflux extracted three times, each time 1 hour; alcohol precipitation, extract purification treatment, the water extract was concentrated to the relative density of 1.05-1.15 (80 ° C), alcohol precipitation concentration of 70%, for 24 hours. Forming process research, the effects of the type and amount of flavoring agent, and determine the prescription, specifications, usage and dosage and terminal sterilization method. Pilot test, three batches of 10 times the prescribed amount of Gardenia Black Bean Soup oral liquid preparation process method is feasible and stable parameters suitable mass production. The study of quality standards, using thin-layer chromatography gardenia Black Bean Soup oral solution gardenia and Seme sojae qualitative identification; ultraviolet spectrophotometry of total flavonoids; HPLC determination of geniposide content . And the identification and determination of a methodological study. The results show that: the established method reproducibility, strong specificity, precision, recovery, etc. to meet the requirements. The gardenia the Miso Soup oral quality standard can be effective control of the quality of the preparation. Preliminary stability study, through the store six months of initial stability were investigated in three batches of samples at room temperature, to prove the quality of the preparation is stable and controllable. Pharmacodynamic study of depression model to explore Gardenia Black Bean Soup oral solution in antidepressant efficacy. Reserpine-induced depression model mice, gardenia Black Bean Soup oral liquid of high, medium and low dose group can effectively resist the reserpine-induced temperature drops, high, middle dose group against ptosis and akinesia; despair due to acute stress model, gardenia Black Bean Soup oral solution can reduce the mouse tail suspension fixed time and rats in the water floating and fixed time.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology
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