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Study on Application of Micro-Ball Extraction in the Drug Analysis

Author: ZhangXiaoFei
Tutor: YuYuanHua
School: Changchun University of Science and Technology
Course: Inorganic Chemistry
Keywords: Beads extraction Gas Chromatography Blood samples Poison
CLC: O658.2
Type: Master's thesis
Year: 2011
Downloads: 34
Quote: 0
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Abstract


Over the development of modern science and technology , led to a variety of large-scale analysis of the popularity of the instrument , which has greatly improved the detection sensitivity of the poison . The sample preparation method has become constraints is advanced analytical methods bottleneck factors , many analysts workers to focus on the study of the pre-treatment method . In the field of toxicology analysis , due to the continued expansion of toxic species and poison chemical properties of different methods of pre-treatment , higher demands , there are many different interfering substances in biological samples , therefore good separation method is to ensure that one of the necessary conditions for the correct identification of the conclusions . Current efforts to establish a simple , rapid , accurate and variety of poisons synchronous sample enrichment and separation methods is imperative . In this paper, a new biological sample pre-treatment methods - beads extraction and bead extraction method to extract the blood in the common drugs , hypnotics, sedatives and organophosphate insecticides , poisons , drugs and other criminal phenomena to combat The case provides a scientific basis . Beads extraction technology can also be used in the field of environmental quality monitoring , biological engineering , food safety is a broad development prospects before processing technology . In this paper, Cleanert amino resins established a new sample preparation method bead extraction method . To arrive at the microbeads optimized extraction conditions , select the caffeine as a target extract solution ionic strength , pH, extraction time , and eluent amount of extraction efficiency were investigated . The human blood poisoning category , hypnotic sedative drugs and organophosphorus pesticides beads extraction - gas chromatographic method . Mainly on the pH of the solution on the extraction efficiency were investigated . Experimental results show that the optimum extraction conditions of the above three types of drugs in human blood and to adjust the pH of the sample solution , based on the acid-base properties of the drug , the shock to extract 30 minutes using a vortex mixer end O.1mL solvent desorption . The recoveries of the various drugs are up to 70 % or more , and the relative standard deviation of less than 5% , which can meet the actual demand of the case .

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CLC: > Mathematical sciences and chemical > Chemistry > Analytical Chemistry > Separation of elements and compounds > Extraction method
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