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Objective: specific COX-2 inhibitor celecoxib celecoxib is a clinical orthopedic common anti-inflammatory and analgesic drugs , this article through the establishment of a closed fracture model in mice to explore the impact of celecoxib on fracture healing . Methods : 36 mice by closed fractures strike caused the interrupt non-displaced fracture of the right femur after randomly mice were divided into three groups : saline group , low-dose celecoxib celecoxib group ( 2mg/kg/day . ) , large doses of celecoxib group ( 4mg/kg/day ) . All mice by gavage , 2, 3, and 4 weeks after mice were sacrificed , gross specimens callus measurement radiology and histological evaluation . Results: Specimens callus measurement display : two weeks , the saline control group with low-dose celecoxib group , high-dose celecoxib celecoxib group the presence of a statistically significant difference ( P lt; 0.01 ) , but small doses of celecoxib celecoxib group and high-dose celecoxib celecoxib group no statistically significant difference (P gt; 0.05). Three weeks , four weeks was no statistically significant difference between the groups (P gt; 0.05). Radiology score : 2 weeks , the control group and the two - drug group there is a significant statistical difference ( P lt; 0.01 ) , the two - drug group compared significant difference ( P lt; 0.05 ) . 3 to 4 weeks , the control group and two groups of drug group , there was still a significant difference ( P lt; 0.01 ) , the two - drug group , no significant difference ( P gt ; 0.05) . The histological scores : two weeks , three weeks , three groups are compared with each other has a statistically significant difference ( P lt; 0.01 ) , 4 weeks , the control group and two groups of drug group still has a statistically significant difference (P lt ; 0.01 ) , while no significant differences between the medication group (P gt; 0.05). Conclusion: large doses , small doses of celecoxib mice fracture healing were significantly reduced. On fracture healing in early fracture healing , large doses of celecoxib to inhibit the more obvious , but late to fracture healing , two different doses of celecoxib inhibition of fracture healing in mice did not differ significantly .
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