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Study on the Targeting of Dextran Magnetic Carriers in the Rat Abdominal Skin Flap

Author: KangWenBo
Tutor: GuoShuZhong
School: Fourth Military Medical University
Course: Surgery
Keywords: Magnetic carrier Abdominal flap Targeting
CLC: R96
Type: Master's thesis
Year: 2011
Downloads: 14
Quote: 0
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Abstract


Objective: To explore the appropriate role of the external magnetic field dextran and cross-linked dextran magnetic carrier targeting in the rat abdominal skin flap , magnetic immune suppression drugs to combat allogeneic rat abdominal skin flap transplantation immune rejection prepare . Methods: 35 male Sprague-Dawley (SD) rats , weighing 250 -350g , were randomly divided into the following seven groups , five in each group : ① the glucan magnetic carrier femoral artery infusion , 2400GS role of the external magnetic field 1h group ( standard control group ) ; ② crosslinked dextran magnetic carrier femoral artery infusion 2400GS external field 1H ; a ③ glucan magnetic carrier femoral vein infusion , 2400GS external field 1H ; ④ dextran magnetic vector stocks arterial infusion , 0GS role of the external magnetic field 1h group ; the ⑤ glucan magnetic carrier femoral artery infusion , 6000GS role of the external magnetic field 1h group ; the ⑥ glucan magnetic carrier femoral artery infusion , 2400GS role of the external magnetic field 3h group ; ⑦ blank group. The rat abdominal skin flap flap inside the iron concentration was measured using atomic emission spectrometry , indirectly reflect the enrichment of the magnetic carrier in the organization . Results : ( 1 ) two magnetic carrier comparison ( ① ② group ) , in rat abdominal skin flap , cross- linked dextran iron concentration of the magnetic carrier group 245.2 ± 6.84μg / g higher than the dextran magnetic particles group 168.8 ± 8.70μg / g , P lt; 0.05 . The ⑵ two infusions ways of comparing ( ① ③ group and the first group ) , rat abdominal skin flap , the iron concentration of the femoral artery infusion group 168.8 ± 8.70μg / g and femoral vein infusion group 155.0 ± 5.00μg / g compared to P gt ; 0.05 , not statistically significant . ( 3 ) different external magnetic field intensity compare ( first ① groups and the first ④ , ⑤ group ) , in rat abdominal skin flap the 6000GS group iron concentration of 210.4 ± 2.70μg / g higher than the 2400GS group 168.8 ± 8.70μg / g, P lt ; 0.05, which was higher than the 0GS group 126.2 ± 13.26μg / g , P lt ; 0.05. ⑷ different external magnetic field ( ① and the ⑥ group ) spend more time in the rat abdominal skin flap , the the 3h group of iron concentration 235.8.4 ± 13.55μg / g higher than the 1h group 168.8 ± 8.70μg / g, P lt; 0.05. Conclusion: The external magnetic field , the magnetic carrier of dextran can be targeted gathered in a rat abdominal skin flap , and the concentration and the nature of the magnetic carrier , was positively correlated with the external magnetic field intensity and its duration of action and has nothing to do with the infusion .

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