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Objective To study the clinical features of respiratory infection caused by WU polyomavirus ( WUPyV) in children..Material and methodsMaterial: From January 2008 to September 2010, throat swab samples were collected from1701 children who were hospitalized with respiratory tract infection in Second Affiliated Hospital of Shantou University Medical College, and the clinical datas about WUPyV-positive cases or WUPyV-positive cases were collected including age, gender, symptoms and signs.Methods: 1、Multiplex PCR was applied to detect 10 kinds of viruses including WU Polyomavirus (WUPyV), respiratory syncytial virus (RSV), Boca virus (HBoV), adenovirus (ADV), rhinovirus (RhV), influenza virus A, B type (FluA, FluB), parainfluenza virus type 1,3 (PIV1, PIV3 ) and Human metapneumovirus (hMPV).2、To compare the clinical datas of WUPyV-positive cases with that of WUPyV-positive cases.Results1、There were 1215 positive samples (71.4%) in 1701 specimens, with 46 WUPyV-positive cases (2.7%) and 365 RSV-positive cases (21.5%). There were 22 cases (47.8%) and 88 cases (24.1%) of simple infection for WUPyV and RSV.2、The positive rate of WUPyV peaked in spring, while the positive rate of RSV reached its peak in winter; the average age of children with WUPyV infection was 26.23 months old, greater than that of children with RSV infection.3、Clinical characteristics of children infected with WUPyV and RSV are similar, but Coughing, wheezing were more common in children with RSV infection; There was no significant difference in the aspects of signs in the lungs, WBC count, CRP value, length of stay and severity of disease for both virus infection. The disease caused by WUPyV infection is mainly bronchial pneumonia, while the disease caused by RSV infection is mainly capillary bronchitis. Conclusions1、Respiratory tract infections in children were partly caused by WUPyV infection;2、WUPyV infection were more common in the 1-3 age group children; the positive rate of WUPyV peaked in spring,and its clinical manifestations are similar to that of normal bronchial pneumonia and bronchitis, but rare in serious cases.3、WUPyV infection has a higher rate of co-infection with other viruses, especially with RSV.
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