Dissertation > Excellent graduate degree dissertation topics show

The Synthesis and Structural Modification of Novel Natural Product-Selaginellin L

Author: LiuRui
Tutor: TanGuiShan
School: Central South University
Course: Medicinal Chemistry
Keywords: mGluR5 antagonists Selaginellin L ND-Selaginellin MPEPa
CLC: R284.1
Type: Master's thesis
Year: 2011
Downloads: 56
Quote: 1
Read: Download Dissertation


Currently , the screening found mGluR5 antagonist synthetic chemical entities are based on computer-aided drug design compound libraries . So far, no mGluR5 antagonist derived from a natural product literature reports. 2007 Lanzhou University Lister first isolated from Selaginella sinensis to new carbon skeleton Selaginellin the alkyne phenolic chemical structure . Subsequently, the experimental group success from Selaginella genus 12 to get Selaginellin series of compounds . Subject early stage of Selaginellin biologically active research and literature analysis , we may speculate Selaginellin L is an excellent natural mGluR5 antagonist . The topic for the first time as a natural product Selaginellin L lead compounds , the to design synthetic the ND-Selaginellin class goal the compound and MPEPa class target compounds . By bromination, Suzuki in Sonogashira diazotization reaction successfully synthesized compound , ND - Selaginellin class compounds 13 and 10 , MPEPa compounds . The structures were confirmed by 1HNMR, 13CNMR modern spectroscopic techniques of related compounds . In addition , the subject , the route of synthesis of the related compounds exploration, where the design of the three target compounds 9 ( 4,4 ??' - dimethoxy -5 - (( 4 - methoxyphenyl) ethynyl ) -2 - methyldibenzo ) in the synthetic route, and successfully opened route 3 ; designed two of the target compound 17 ( 4 ' , 6 - dimethoxy-3 - ((4 - methoxyphenyl) ethynyl ) - 2 - methyl diphenyl ) synthesis route , the two routes to get through successfully . In addition, some important chemical reactions in the field of medicine and chemical , such as bromo , Suzuki, in Sonogashira such as a large number of exploration to find the better method of preparation . The same time, the substrate salt of fluorine boron as the Suzuki reaction , we also found a novel extension of the carbon chain .

Related Dissertations

  1. Studies on the Active Constituents of Swertia Nervosa(G.Don) Wall. and Content Determination of Two Bitter Secoiridoid Glycosides,R284
  2. Chemical constituents of Selaginella,R284
  3. Studies on Chemical Constituent from Selaginella Pulvinata Maxim and Effects of Selaginellin on Senescence of Endothelial Cells,R285
  4. Novel Acetylene Phenolic Compound Selaginellin: Anti-aging of Endothelial Cells and Neurobiology Research,R965
  5. The Total Synthesis of a Flavonoid Glycoside Apigenin-7-O-β-D-glucuronide,R284.1
  6. Study on Extracting Process of Rhizoma Alismatis and Rhizoma Smilacis Glabrae and Their Hypouricemic Effects,R284
  7. Preparation, Evaluation, and Application of Several Natural Product Molecularly Imprinted Polymers,R284.1
  8. Discovery and Biological Activities of Natural Michael Addition Acceptors,R284
  9. The Chemical Constituents of Bryozoan Bugula Neritina L. and Junceella Fragilis from South China Sea,R284
  10. Study on the Secondary Metabolites of Two Fungi from the South China Sea,R284
  11. Study on Extraction and Active Function of the Chemical Composition of Cacumen Platycladi,R284
  12. Study on Phylogenetic Diversity and Bioactivity of Symbiotic Fungi of Coral,R284
  13. Design, Synthesis and Biological Evaluation of Novel Podophyllotoxin Derivatives as Antitumor Agents,R284
  14. Research on the Antidepressive Bioactive Constituents and Analytical Method for Piper Laetispicum C. DC.,R284.1
  15. The Research on the Antioxidant Fat-Solube Compositions of Salicornia Herbacea L.,R284.1
  16. Homoisoflavonoids from Ophiopogon Japonicus and Alkaloids from Elaeocarpus Sphaericus,R284.1
  17. Determination Method and Extraction Purification of Terpenoid Indole Alkaloids in Catharanthus Roseus,R284
  18. Studies on Fingerprint Analysis and Total Flavone Extracts of Saussurea Involucrata ( Kar. Et Kir.) Sch.-Bip.,R284.1
  19. Fundamental Studies on the Chemical Constituents of Brassica Rapa L.seed.,R284
  20. Extraction Condition of Paeoniflorin from Paeonia Lactiflora,R284.2
  21. Selenium Modification of Astragalus Polysaccharide and Its Antioxidant Activity in Vitro,R284.1

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical > Chemical analysis and identification
© 2012 www.DissertationTopic.Net  Mobile